Hanbang Cardio-Renal Research Center & Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 54538, Korea.
Department of Physiology, College of Oriental Medicine, Wonkwang University, Iksan 54538, Korea.
Nutrients. 2020 Dec 17;12(12):3859. doi: 10.3390/nu12123859.
Hypertriglyceridemia is a condition characterized by high triglyceride levels and is a major risk factor for the development of cardiovascular diseases. The present study was designed to investigate the inhibitory effect of roasted (RN), which is a medicinal substance produced by heating lotus leaves, on lipid metabolism in high fat/cholesterol (HFC) diet-induced hypertriglyceridemia. Except for those in the control group, Sprague-Dawley rats were fed an HFC diet for four weeks to induce hypertriglyceridemia. During the next nine weeks, the control, regular diet; HFC, HFC diet, FLU, fluvastatin (3 mg/kg/day); RNL, RN (100 mg/kg/day); RNH, RN (200 mg/kg/day) were orally administered together with the diet, and the experiments were conducted for a total of 13 weeks. The weight of the epididymal adipose tissue, liver, and heart of rats in the HFC diet group significantly increased compared to those in the control group but improved in the RN-treated group. It was also confirmed that vascular function, which is damaged by an HFC diet, was improved after RN treatment. The levels of insulin, glucose, triglycerides, total cholesterol, and low-density lipoprotein increased in the HFC diet group compared to those in the control group, while the administration of RN attenuated these parameters. In addition, the administration of RN significantly reduced the gene expression of both LXR and SREBP-1, which indicated the inhibitory effect of the biosynthesis of triglycerides caused by RN. The results indicated that RN administration resulted in an improvement in the overall lipid metabolism and a decrease in the concentration of triglycerides in the HFC diet-induced rat model of hypertriglyceridemia. Therefore, our findings suggest that the RN can be a candidate material to provide a new direction for treating hypertriglyceridemia.
高脂血症是一种以甘油三酯水平升高为特征的疾病，是心血管疾病发展的主要危险因素。本研究旨在探讨经加热炮制得到的荷叶药材（RN）对高脂/胆固醇（HFC）饮食诱导的高脂血症大鼠脂代谢的抑制作用。除对照组外，其余 Sprague-Dawley 大鼠给予 HFC 饮食 4 周，诱导高脂血症。在接下来的 9 周内，对照组给予普通饮食，HFC 组给予 HFC 饮食，FLU 组给予氟伐他汀（3mg/kg/天），RNL 组给予 RN（100mg/kg/天），RNH 组给予 RN（200mg/kg/天），同时给予饮食进行治疗，实验共进行 13 周。与对照组相比，HFC 饮食组大鼠附睾脂肪组织、肝脏和心脏重量明显增加，但经 RN 处理后有所改善。同时证实，HFC 饮食导致的血管功能受损在 RN 治疗后得到改善。与对照组相比，HFC 饮食组大鼠胰岛素、血糖、甘油三酯、总胆固醇和低密度脂蛋白水平升高，而给予 RN 可减轻这些参数。此外，给予 RN 可显著降低 LXR 和 SREBP-1 的基因表达，表明 RN 抑制了甘油三酯的生物合成。结果表明，给予 RN 可改善整体脂代谢，降低 HFC 饮食诱导的高脂血症大鼠模型中甘油三酯的浓度。因此，我们的研究结果表明，RN 可作为治疗高脂血症的候选物质，为其治疗提供新的方向。
