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(Cav.)Cabrera 叶中一种新的抗糖尿病和抗炎双黄酮。

A new antidiabetic and anti-inflammatory biflavonoid from (Cav.) Cabrera leaves.

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Center of Drug Discovery Research and Development, Ain Shams University, Cairo, Egypt.

出版信息

Nat Prod Res. 2022 Mar;36(5):1182-1190. doi: 10.1080/14786419.2020.1864365. Epub 2020 Dec 28.

DOI:10.1080/14786419.2020.1864365
PMID:33356557
Abstract

A new biflavonoid, luteolin-(6→8'')-apigenin was isolated from 80% methanol extract of (Cav.) Cabrera leaves (Anacardiaceae). The structure was elucidated by 1D and 2D-NMR spectroscopic data. This compound exhibited antidiabetic effect via -amylase assay. Furthermore, it possesses anti-inflammatory activity through membrane stabilization effect on erythrocytes.

摘要

从(Cav.)Cabrera 叶(漆树科)80%甲醇提取物中分离得到一种新的双黄酮类化合物,木犀草素-(6''→8'')-芹菜素。通过 1D 和 2D-NMR 光谱数据阐明了其结构。该化合物通过 -淀粉酶测定表现出抗糖尿病作用。此外,它通过对红细胞的膜稳定作用具有抗炎活性。

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