Groupe de Recherche en Biologie Végétale (GRBV), Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, 3351 boul. des Forges, Trois-Rivières, QC G9A 5H7, Canada.
Genes (Basel). 2020 Dec 31;12(1):51. doi: 10.3390/genes12010051.
Abiotic and biotic stresses induce the formation of reactive oxygen species (ROS), which subsequently causes the excessive accumulation of aldehydes in cells. Stress-derived aldehydes are commonly designated as reactive electrophile species (RES) as a result of the presence of an electrophilic α, β-unsaturated carbonyl group. Aldehyde dehydrogenases (ALDHs) are NAD(P)-dependent enzymes that metabolize a wide range of endogenous and exogenous aliphatic and aromatic aldehyde molecules by oxidizing them to their corresponding carboxylic acids. The ALDH enzymes are found in nearly all organisms, and plants contain fourteen ALDH protein families. In this review, we performed a critical analysis of the research reports over the last decade on plant ALDHs. Newly discovered roles for these enzymes in metabolism, signaling and development have been highlighted and discussed. We concluded with suggestions for future investigations to exploit the potential of these enzymes in biotechnology and to improve our current knowledge about these enzymes in gene signaling and plant development.
非生物和生物胁迫会诱导活性氧（ROS）的形成，ROS 继而导致细胞内醛类物质的过度积累。应激衍生的醛通常被指定为反应性亲电物质（RES），因为它们具有亲电的α，β-不饱和羰基基团。醛脱氢酶（ALDHs）是 NAD（P）依赖性酶，通过将广泛的内源性和外源性脂肪族和芳香族醛分子氧化为相应的羧酸来代谢它们。ALDH 酶几乎存在于所有生物体中，植物含有 14 种 ALDH 蛋白家族。在这篇综述中，我们对过去十年中关于植物 ALDHs 的研究报告进行了批判性分析。强调并讨论了这些酶在代谢、信号转导和发育中的新发现作用。我们最后提出了未来研究的建议，以利用这些酶在生物技术中的潜力，并提高我们目前对这些酶在基因信号转导和植物发育中的认识。
