State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China.
Mikrochim Acta. 2021 Jan 6;188(1):21. doi: 10.1007/s00604-020-04671-3.
In recent years, the abuse of antibiotics has led to the pollution of soil and water environment, not only poultry husbandry and food manufacturing will be influenced to different degree, but also the human body will produce antibody. The detection of antibiotic content in production and life is imperative. In this review, we provide comprehensive information about chemical sensors and biosensors for antibiotic detection. We classify the currently reported antibiotic detection technologies into chromatography, mass spectrometry, capillary electrophoresis, optical detection, and electrochemistry, introduce some representative examples for each technology, and conclude the advantages and limitations. In particular, the optical and electrochemical methods based on nanomaterials are discussed and evaluated in detail. In addition, the latest research in the detection of antibiotics by photosensitive materials is discussed. Finally, we summarize the pros and cons of various antibiotic detection methods and present a discussion and outlook on the expansion of cross-scientific areas. The synthesis and application of optoelectronic nanomaterials and aptamer screening are discussed and prospected, and the future trends and potential impact of biosensors in antibiotic detection are outlined.Graphical abstract.
近年来，抗生素的滥用导致土壤和水环境受到污染，不仅家禽养殖业和食品制造业会受到不同程度的影响，而且人体也会产生抗体。因此，对生产和生活中抗生素含量的检测势在必行。在本文综述中，我们提供了关于抗生素检测的化学传感器和生物传感器的综合信息。我们将目前报道的抗生素检测技术分为色谱法、质谱法、毛细管电泳法、光学检测法和电化学法，为每种技术介绍了一些有代表性的例子，并总结了它们的优缺点。特别地，详细讨论和评估了基于纳米材料的光学和电化学方法。此外，还讨论了光致敏感材料在抗生素检测方面的最新研究进展。最后，我们总结了各种抗生素检测方法的优缺点，并对跨学科领域的拓展进行了讨论和展望。讨论并展望了光电纳米材料的合成与应用以及适体的筛选，概述了生物传感器在抗生素检测方面的未来趋势和潜在影响。
