Zou Xianyun, Xu Maoyuan, Pan Shuhui, Gan Lu, Zhang Song, Chen Hongxiang, Liu Dawei, Lu Xinpei, Ostrikov Kostya Ken
State Key Lab of Advanced Electromagnetic Engineering and Technology, School of Electronic and Electrical Engineering, Huazhong University of Science and Technology, WuHan, HuBei 430074, China.
IFSA Collaborative Innovation Center, Shanghai Jiao Tong University, Shanghai 200240, China.
ACS Biomater Sci Eng. 2019 Mar 11;5(3):1611-1622. doi: 10.1021/acsbiomaterials.9b00125. Epub 2019 Mar 1.
The "third-generation" cooking oil based drug, named plasma activated oil (PAO), is produced in cheap olive oil by a single-step, room temperature, energy-efficient, and environment-friendly dry plasma-enabled process. The streamer-surface discharge generates abundant energetic species, atomic oxygen at the plasma-oil interface. The otherwise challenging dissociation of C═C double bonds by energetic species and oxidation by the plasma generated atomic oxygen is the key mechanism to produce the HO active species and carboxylic acid in the PAO. It is shown that the peroxide value and acid value of PAO are 7.5 times and 57% higher than those of the traditional ozonated oil, respectively. Different from plasma activated water whose shelf life was less than 1 week, PAO could be stored at room temperature for at least 3 months, and a shelf life of up to 1 year is expected. We further reveal that the PAO can not only sterilize the wound, but also promote more release of growth factor such as VEGF and CD34; therefore, the wound healing of PAO is 28.5% faster than that of the control group.
第三代食用油基药物，名为等离子体活化油（PAO），是通过一步法、室温、节能且环保的干式等离子体工艺在廉价橄榄油中生产的。流光-表面放电会产生大量活性物质，即在等离子体-油界面处产生原子氧。高能物种对C═C双键进行的原本具有挑战性的解离以及等离子体产生的原子氧的氧化作用，是在PAO中产生羟基活性物种和羧酸的关键机制。结果表明，PAO的过氧化值和酸值分别比传统臭氧化油高7.5倍和57%。与保质期不到1周的等离子体活化水不同，PAO可在室温下储存至少3个月，预计保质期长达1年。我们进一步发现，PAO不仅可以对伤口进行消毒，还能促进更多生长因子如血管内皮生长因子（VEGF）和CD34的释放；因此，PAO处理的伤口愈合速度比对照组快28.5%。
