Gomez-Illan Ramon, Reina Raul, Barbado David, Sabido Rafael, Moreno-Navarro Pedro, Roldan Alba
Sport Research Centre, Department of Sport Sciences, Miguel Hernandez University, 03202 Elche, Spain.
Medicina (Kaunas). 2020 Dec 20;56(12):718. doi: 10.3390/medicina56120718.
: Fatigue is one of the most disabling symptoms that limit daily life activities in persons with multiple sclerosis (pwMS). This study aimed to evaluate the effects of maximal strength training (MST) on perceived-fatigue and functional mobility in pwMS. : 26 participants with MS were balanced according to their pre-intervention fatigue scores and distributed into an MST group ( = 13) and a control group (CG; = 13). The MST group completed eight weeks using high loads, evaluating detraining after ten weeks. Quadriceps and hamstring isokinetic (QPT; HPT) and isometric (QPT; HPT) peak torques were assessed using an isokinetic dynamometer. Effect size differences were estimated with the Hedges' index (). Fatigue was evaluated through the Fatigue Severity Scale (FSS), while functional mobility was assessed via the Timed Up and Go Test (TUG). : The MST significantly improved all the strength measurements after the intervention (Δ6.43-29.55%; < 0.05) compared to the control group. FSS showed a significant reduction (59.97%, = 5.41, large). The MST group also reduced the TUG time (19.69%; = 0.93, large) compared to the control group. Improvements caused by the intervention did not remain after a 10-week follow-up, with decreases in strength performance from 4.40% to 13.86% ( = 0.24-0.56, small to moderate), 112.08% in the FSS ( = -3.88, large), and 16.93% in TUG ( = -1.07, large). : MST (up to 90% 1RM) seems to be a feasible and useful way to obtain clinically relevant improvements in the perceived-fatigue symptoms and functional mobility. Still, symptom improvements decrease after a 10-week detraining period.
疲劳是限制多发性硬化症患者（pwMS）日常生活活动的最致残症状之一。本研究旨在评估最大力量训练（MST）对pwMS患者感知疲劳和功能移动性的影响。26名MS患者根据干预前的疲劳评分进行均衡分组，分为MST组（n = 13）和对照组（CG；n = 13）。MST组进行为期八周的高负荷训练，并在十周后评估停训情况。使用等速测力计评估股四头肌和腘绳肌的等速（QPT；HPT）和等长（QPT；HPT）峰值扭矩。用Hedges' g指数（g）估计效应大小差异。通过疲劳严重程度量表（FSS）评估疲劳，同时通过计时起立行走测试（TUG）评估功能移动性。与对照组相比，干预后MST显著改善了所有力量测量指标（Δ6.43 - 29.55%；p < 0.05）。FSS显示显著降低（59.97%，p = 5.41，大效应）。与对照组相比，MST组的TUG时间也缩短了（19.69%；p = 0.93，大效应）。干预导致的改善在10周随访后未持续，力量表现下降了4.40%至13.86%（p = 0.24 - 0.56，小至中等效应），FSS上升了112.08%（p = -3.88，大效应），TUG上升了16.93%（p = -1.07，大效应）。MST（高达90% 1RM）似乎是一种可行且有用的方法，可在感知疲劳症状和功能移动性方面获得临床相关改善。然而，在10周的停训期后，症状改善会下降。
