Ophthalmology Department, Kayseri City Training and Research Hospital, Kocasinan, Kayseri, Turkey.
Jpn J Ophthalmol. 2021 Mar;65(2):227-236. doi: 10.1007/s10384-020-00800-w. Epub 2021 Jan 9.
This study used spectral domain-optical coherence tomography (SD-OCT) to evaluate individual retinal layer thickness in eyes with macula-off rhegmatogenous retinal detachment (RRD) treated with silicone oil (SiO) or gas endotamponades.
This was a retrospective, interventional, comparative study.
The study included 86 eyes of 43 patients who were divided into 3 groups according to endotamponades: SiO, perfluoropropane (C3F8), and sulfur hexafluoride (SF6). The affected eyes were compared with the fellow eyes of the same patient via SD-OCT automated segmentation analysis. Patients with a follow-up of at least 6 months were included in the final analysis. Macular segmentation including the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE), inner retinal layers (IRLs), and outer retinal layers (ORLs) was analyzed.
In the SiO group, the mean thickness of each retinal layer including the RNFL, GCL, IPL, ONL, and IRLs within a 1-mm ETDRS subfield of the affected eyes was significantly lower than that of the fellow eyes (P = 0.036, P = 0.028, P = 0.003, P < 0.001, P = 0.013, respectively). There was no significant difference in the C3F8 and SF6 groups (all P > 0.05). The difference between the ONL and IRLs in the SiO-treated eyes differed significantly from that of the gas groups (P = 0.001 and P = 0.045, respectively) The difference in the GCL thickness of the affected eyes and healthy eyes showed a significant correlation with postoperative BCVA changes in the SiO, C3F8, and SF6 groups (P = 0.041, P = 0.048, and P = 0.045, respectively).
The findings of our study show that endotamponades used in RRD surgery may have different effects on retinal layers. In addition, SiO may cause undesirable effects on the retinal layers.
本研究采用频域光相干断层扫描（SD-OCT）评估硅油（SiO）或气体内填充治疗黄斑裂孔孔源性视网膜脱离（RRD）患者的视网膜各层厚度。
这是一项回顾性、干预性、对比研究。
该研究纳入了 43 名患者的 86 只眼，根据内填充剂将患者分为 3 组：SiO、全氟丙烷（C3F8）和六氟化硫（SF6）。通过 SD-OCT 自动分层分析，将患眼与同一患者的对侧眼进行比较。纳入至少随访 6 个月的患者进行最终分析。对包括视网膜神经纤维层（RNFL）、节细胞层（GCL）、内丛状层（IPL）、内核层（INL）、外丛状层（OPL）、外核层（ONL）、视网膜色素上皮（RPE）、内视网膜层（IRLs）和外视网膜层（ORLs）在内的黄斑区进行分段分析。
在 SiO 组中，患眼 1mm ETDRS 亚区各视网膜层包括 RNFL、GCL、IPL、ONL 和 IRLs 的平均厚度明显低于对侧眼（P=0.036、P=0.028、P=0.003、P<0.001、P=0.013）。C3F8 和 SF6 组之间无显著性差异（均 P>0.05）。SiO 治疗眼的 ONL 和 IRLs 之间的差异与气体组之间的差异有显著性差异（P=0.001 和 P=0.045）。SiO、C3F8 和 SF6 组患眼和健眼 GCL 厚度的差异与术后 BCVA 变化呈显著相关（P=0.041、P=0.048 和 P=0.045）。
本研究结果表明，RRD 手术中使用的内填充剂可能对视网膜层有不同的影响。此外，SiO 可能对视网膜层产生不良影响。
