越来越多的证据表明，接触氯乙烯的工人患癌症的几率在上升。
Increasing evidence of the rise of cancer in workers exposed to vinylchloride.
作者信息
Smulevich V B, Fedotova I V, Filatova V S
机构信息
All-Union Cancer Research Centre, AMS USSR, Moscow.
出版信息
Br J Ind Med. 1988 Feb;45(2):93-7. doi: 10.1136/oem.45.2.93.
Abstract
The results of a cancer mortality study among workers employed in the production of vinylchloride and polyvinylchloride between 1939 and 1977 suggest a significant increase in deaths from malignancies of the lymphatic and haemopoietic tissues. Mortality for tumours of the digestive organs, respiratory system, bone and connective tissues, brain, and skin are also greater than in the general population. There were no registered cases of liver angiosarcoma in the study cohort during the follow up period. The risk of cancer was highest among the workers exposed to concentrations of VC of 300 mg/m3 and more who had worked at the plant for 15 to 19 years. The relatively high number of leukaemias and lymphomas in the study group and the absence of liver angiosarcomas probably reflects specific carcinogenic action of different doses of vinylchloride.
摘要
一项针对1939年至1977年间从事氯乙烯和聚氯乙烯生产的工人的癌症死亡率研究结果表明，淋巴和造血组织恶性肿瘤导致的死亡人数显著增加。消化器官、呼吸系统、骨骼和结缔组织、大脑及皮肤肿瘤的死亡率也高于普通人群。在随访期间，研究队列中未登记到肝血管肉瘤病例。在工厂工作15至19年且接触氯乙烯浓度达300毫克/立方米及以上的工人患癌风险最高。研究组中白血病和淋巴瘤数量相对较多以及未出现肝血管肉瘤，这可能反映了不同剂量氯乙烯特定的致癌作用。
相似文献
1
Increasing evidence of the rise of cancer in workers exposed to vinylchloride.越来越多的证据表明，接触氯乙烯的工人患癌症的几率在上升。
Br J Ind Med. 1988 Feb;45(2):93-7. doi: 10.1136/oem.45.2.93.
2
Incidence of cancer among vinylchloride and polyvinylchloride workers: further evidence for an association with malignant melanoma.氯乙烯和聚氯乙烯工人的癌症发病率：与恶性黑色素瘤有关联的进一步证据。
Br J Ind Med. 1987 Oct;44(10):718-9. doi: 10.1136/oem.44.10.718.
3
Cohort and case-control analyses of workers exposed to vinyl chloride: an update.氯乙烯暴露工人的队列研究和病例对照分析：最新进展。
J Occup Med. 1989 Jun;31(6):518-23. doi: 10.1097/00043764-198906000-00007.
4
Toxicity of vinyl chloride and poly(vinyl chloride): a critical review.氯乙烯和聚氯乙烯的毒性：批判性综述。
Environ Health Perspect. 1983 Oct;52:61-6. doi: 10.1289/ehp.835261.
5
Incidence of cancer among vinyl chloride and polyvinyl chloride workers.氯乙烯和聚氯乙烯工人中的癌症发病率。
Br J Ind Med. 1984 Feb;41(1):25-30. doi: 10.1136/oem.41.1.25.
6
Incidence of cancer among vinyl chloride and polyvinyl chloride workers: further evidence for an association with malignant melanoma.氯乙烯和聚氯乙烯工人中的癌症发病率：与恶性黑色素瘤有关联的进一步证据。
Br J Ind Med. 1987 Apr;44(4):278-80. doi: 10.1136/oem.44.4.278.
7
A mortality study of vinyl chloride monomer workers employed in the United Kingdom in 1940-1974.一项针对1940年至1974年在英国受雇的氯乙烯单体工人的死亡率研究。
Scand J Work Environ Health. 1988 Jun;14(3):153-60. doi: 10.5271/sjweh.1937.
8
Cancer mortality of a group of Canadian workers exposed to vinyl chloride monomer.一组接触氯乙烯单体的加拿大工人的癌症死亡率。
J Occup Med. 1981 Oct;23(10):671-6. doi: 10.1097/00043764-198110000-00009.
9
Two possible cases of angiosarcoma of the liver in a group of Swedish vinyl chloride-polyvinyl chloride workers.一组瑞典氯乙烯-聚氯乙烯工人中可能出现的两例肝血管肉瘤病例。
Ann N Y Acad Sci. 1975 Jan 31;246:249-50. doi: 10.1111/j.1749-6632.1975.tb51099.x.
10
Effects of exposure to vinyl chloride. An assessment of the evidence.接触氯乙烯的影响。证据评估。
Scand J Work Environ Health. 1988 Apr;14(2):61-78. doi: 10.5271/sjweh.1943.
引用本文的文献
1
Mortality for Lung Cancer among PVC Baggers Employed in the Vinyl Chloride Industry.聚氯乙烯工人肺癌死亡率。
Int J Environ Res Public Health. 2022 May 20;19(10):6246. doi: 10.3390/ijerph19106246.
2
Association between occupational exposures and sarcoma incidence and mortality: systematic review and meta-analysis.职业暴露与肉瘤发病率和死亡率的关系：系统评价和荟萃分析。
Syst Rev. 2021 Aug 13;10(1):231. doi: 10.1186/s13643-021-01769-4.
3
Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013.美国全行业氯乙烯队列中氯乙烯的定量估计暴露量与肝血管肉瘤和肝细胞癌风险：截至2013年的死亡率更新
Occup Environ Med. 2017 Oct;74(10):709-716. doi: 10.1136/oemed-2016-104051. Epub 2017 May 10.
4
Vinyl chloride: a case study of data suppression and misrepresentation.氯乙烯：数据压制与失实陈述的案例研究
Environ Health Perspect. 2005 Jul;113(7):809-12. doi: 10.1289/ehp.7716.
5
Periportal fibrosis and other liver ultrasonography findings in vinyl chloride workers.氯乙烯作业工人的门周纤维化及其他肝脏超声检查结果
Occup Environ Med. 2003 Jan;60(1):60-5. doi: 10.1136/oem.60.1.60.
6
Historical cohort study of 10 109 men in the North American vinyl chloride industry, 1942-72: update of cancer mortality to 31 December 1995.1942年至1972年北美氯乙烯行业10109名男性的历史性队列研究：截至1995年12月31日癌症死亡率的更新情况。
Occup Environ Med. 2000 Nov;57(11):774-81. doi: 10.1136/oem.57.11.774.
7
Vinyl chloride: still a cause for concern.氯乙烯：仍然令人担忧。
Environ Health Perspect. 2000 Jul;108(7):579-88. doi: 10.1289/ehp.00108579.
8
Industrial workers' health and environmental pollution under the new international division of labor: the Taiwan experience.新国际劳动分工下的产业工人健康与环境污染：台湾经验
Am J Public Health. 1997 Jul;87(7):1223-31. doi: 10.2105/ajph.87.7.1223.
9
Occupational risk factors for female breast cancer: a review.女性乳腺癌的职业风险因素：综述
Occup Environ Med. 1996 Mar;53(3):145-56. doi: 10.1136/oem.53.3.145.
本文引用的文献
1
Carcinogenicity bioassays of vinyl chloride monomer: a model of risk assessment on an experimental basis.氯乙烯单体的致癌性生物测定：基于实验的风险评估模型
Environ Health Perspect. 1981 Oct;41:3-29. doi: 10.1289/ehp.81413.
2
[Modern concepts of the etiology and pathogenesis of lung cancer].[肺癌病因及发病机制的现代概念]
Vopr Onkol. 1982;28(2):3-9.
3
Oncogenic response of rat skin, lungs, and bones to vinyl chloride.大鼠皮肤、肺和骨骼对氯乙烯的致癌反应。
Cancer Res. 1971 May;31(5):516-22.
4
Occupational acroosteolysis. Report of 31 cases.职业性肢端骨质溶解症。31例报告。
JAMA. 1967 Aug 21;201(8):577-81. doi: 10.1001/jama.201.8.577.
5
Angiosarcoma of liver in the manufacture of polyvinyl chloride.氯乙烯制造过程中发生的肝血管肉瘤。
J Occup Med. 1974 Mar;16(3):150-1.
6
[Scleroderma like skin changes. Raynaud's syndrome and acroosteolyses in workers in the polyvinyl chloride producing industry].[硬皮病样皮肤改变。聚氯乙烯生产行业工人的雷诺综合征和肢端骨质溶解]
Dtsch Med Wochenschr. 1972 Dec 8;97(49):1922-3.
7
Proportional mortality among vinyl-chloride workers.氯乙烯工人中的比例死亡率。
Lancet. 1974 Aug 17;2(7877):397-8. doi: 10.1016/s0140-6736(74)91771-1.
8
Vinyl chloride exposure in a controlled industrial environment. A long-term mortality experience in 594 employees.在可控工业环境中接触氯乙烯。594名员工的长期死亡率情况。
Arch Environ Health. 1975 Jul;30(7):333-9. doi: 10.1080/00039896.1975.10666716.
9
Neoplastic risk among workers exposed to vinyl chloride.接触氯乙烯的工人的肿瘤风险。
Ann N Y Acad Sci. 1976;271:40-8. doi: 10.1111/j.1749-6632.1976.tb23091.x.
10
Mortality and cancer morbidity in a group of Swedish VCM and PCV production workers.一组瑞典氯乙烯单体（VCM）和聚氯乙烯（PVC）生产工人的死亡率和癌症发病率。
Environ Health Perspect. 1976 Oct;17:167-70. doi: 10.1289/ehp.17-1475258.
Zotero 插件