Smulevich V B, Fedotova I V, Filatova V S
All-Union Cancer Research Centre, AMS USSR, Moscow.
Br J Ind Med. 1988 Feb;45(2):93-7. doi: 10.1136/oem.45.2.93.
The results of a cancer mortality study among workers employed in the production of vinylchloride and polyvinylchloride between 1939 and 1977 suggest a significant increase in deaths from malignancies of the lymphatic and haemopoietic tissues. Mortality for tumours of the digestive organs, respiratory system, bone and connective tissues, brain, and skin are also greater than in the general population. There were no registered cases of liver angiosarcoma in the study cohort during the follow up period. The risk of cancer was highest among the workers exposed to concentrations of VC of 300 mg/m3 and more who had worked at the plant for 15 to 19 years. The relatively high number of leukaemias and lymphomas in the study group and the absence of liver angiosarcomas probably reflects specific carcinogenic action of different doses of vinylchloride.
一项针对1939年至1977年间从事氯乙烯和聚氯乙烯生产的工人的癌症死亡率研究结果表明，淋巴和造血组织恶性肿瘤导致的死亡人数显著增加。消化器官、呼吸系统、骨骼和结缔组织、大脑及皮肤肿瘤的死亡率也高于普通人群。在随访期间，研究队列中未登记到肝血管肉瘤病例。在工厂工作15至19年且接触氯乙烯浓度达300毫克/立方米及以上的工人患癌风险最高。研究组中白血病和淋巴瘤数量相对较多以及未出现肝血管肉瘤，这可能反映了不同剂量氯乙烯特定的致癌作用。
