Matthewson K, Pugh S, Northfield T C
Gastroenterology Unit, St James Hospital, Balham.
Gut. 1988 Jan;29(1):70-4. doi: 10.1136/gut.29.1.70.
In order to identify factors associated with peptic ulcers which present with bleeding rather than with pain, we have prospectively evaluated patient and endoscopic features in 139 consecutive patients presenting with acute bleeding and 74 presenting with pain found to have peptic ulceration at endoscopy. Patients with bleeding were more likely to have taken non-steroidal anti-inflammatory drugs within the preceding four weeks (58% v 18%, p less than 0.001). They were older (66 v 51 years, p less than 0.001), more likely to have had a previous ulcer complication (21% v 1%, p less than 0.001), and to have an ulcer diameter greater than 20 mm (27% v 6%, p less than 0.05). The presence of one or more of these features in a patient who develops a peptic ulcer appears to be associated with a greater likelihood of presentation with a gastrointestinal haemorrhage.
为了确定与以出血而非疼痛为表现的消化性溃疡相关的因素，我们前瞻性地评估了139例连续出现急性出血的患者以及74例因疼痛就诊且在内镜检查中发现有消化性溃疡的患者的患者特征和内镜特征。出血患者在前四周内服用非甾体抗炎药的可能性更大（58% 对18%，p<0.001）。他们年龄更大（66岁对51岁，p<0.001），既往有溃疡并发症的可能性更大（21% 对1%，p<0.001），且溃疡直径大于20mm的可能性更大（27% 对6%，p<0.05）。消化性溃疡患者出现这些特征中的一种或多种似乎与发生胃肠道出血的可能性更大有关。
