Gulati Karan, Li Tao, Ivanovski Sašo
School of Dentistry, The University of Queensland, 288 Herston Road, Herston, Queensland 4006, Australia.
Department of Prosthodontics, School of Stomatology, Capital Medical University, Beijing 100069, People's Republic of China.
ACS Biomater Sci Eng. 2018 Sep 10;4(9):3125-3131. doi: 10.1021/acsbiomaterials.8b00829. Epub 2018 Aug 23.
Combining the microroughness of current titanium implants, which promotes accelerated bone integration, with nanotopography for enhanced bioactivity/drug-release may be an ideal solution to address therapeutic challenges inside the bone microenvironment. We hereby present single-step electrochemical anodization using conditioned electrolyte to enable fabrication of aligned titania nanopores with preserved microscale features of the underlying titanium implant. This is applicable toward the fabrication of mechanically robust and clinically translatable next-generation orthopedic/dental implants with dual-topography including "gold-standard" microroughness and superimposed "bioactive" nanotopography.
将目前可促进加速骨整合的钛植入物的微观粗糙度与用于增强生物活性/药物释放的纳米拓扑结构相结合，可能是应对骨微环境内治疗挑战的理想解决方案。我们在此展示了使用经过预处理的电解质进行单步电化学阳极氧化，以制造具有底层钛植入物微观尺度特征的对齐二氧化钛纳米孔。这适用于制造具有机械强度且可临床转化的下一代骨科/牙科植入物，其具有包括“金标准”微观粗糙度和叠加的“生物活性”纳米拓扑结构的双拓扑结构。
