药用蘑菇：生物活性化合物、用途和临床试验。
Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials.
机构信息
Department of Agricultural, Food and Forest Sciences, University of Palermo, Viale delle Scienze, Bldg. 5, I-90128 Palermo, Italy.
Department of Agricultural and Environmental Science, University of Bari Aldo Moro, Via Amendola 165/A, I-70126 Bari, Italy.
出版信息
Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634.
Abstract
Medicinal mushrooms have important health benefits and exhibit a broad spectrum of pharmacological activities, including antiallergic, antibacterial, antifungal, anti-inflammatory, antioxidative, antiviral, cytotoxic, immunomodulating, antidepressive, antihyperlipidemic, antidiabetic, digestive, hepatoprotective, neuroprotective, nephroprotective, osteoprotective, and hypotensive activities. The growing interest in mycotherapy requires a strong commitment from the scientific community to expand clinical trials and to propose supplements of safe origin and genetic purity. Bioactive compounds of selected medicinal mushrooms and their effects and mechanisms in in vitro and in vivo clinical studies are reported in this review. Besides, we analyzed the therapeutic use and pharmacological activities of mushrooms.
摘要
药用蘑菇具有重要的健康益处，并表现出广泛的药理活性，包括抗过敏、抗菌、抗真菌、抗炎、抗氧化、抗病毒、细胞毒性、免疫调节、抗抑郁、抗高血脂、抗糖尿病、助消化、保肝、神经保护、肾保护、骨保护和降血压活性。对真菌疗法的兴趣日益浓厚，这需要科学界做出坚定承诺，扩大临床试验，并提出安全来源和遗传纯度的补充剂。本文综述了选定药用蘑菇的生物活性化合物及其在体外和体内临床研究中的作用和机制。此外，我们分析了蘑菇的治疗用途和药理活性。
相似文献
1
Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials.药用蘑菇：生物活性化合物、用途和临床试验。
Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634.
2
A review of the therapeutic and biological effects of edible and wild mushrooms.食用蘑菇和野生蘑菇的治疗和生物学效应综述。
Bioengineered. 2021 Dec;12(2):11239-11268. doi: 10.1080/21655979.2021.2001183.
3
Mushroom-Based Supplements in Italy: Let's Open Pandora's Box.意大利的蘑菇类膳食补充剂：让我们打开潘多拉的盒子。
Nutrients. 2023 Feb 2;15(3):776. doi: 10.3390/nu15030776.
4
Current findings, future trends, and unsolved problems in studies of medicinal mushrooms.药用蘑菇研究的当前发现、未来趋势和未解决问题。
Appl Microbiol Biotechnol. 2011 Mar;89(5):1323-32. doi: 10.1007/s00253-010-3067-4. Epub 2010 Dec 29.
5
Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer.食用/药用蘑菇在乳腺癌中的抗癌潜力。
Int J Mol Sci. 2023 Jun 14;24(12):10120. doi: 10.3390/ijms241210120.
6
The role of culinary-medicinal mushrooms on human welfare with a pyramid model for human health.食用药用菌对人类福祉的作用及人类健康的金字塔模型
Int J Med Mushrooms. 2012;14(2):95-134. doi: 10.1615/intjmedmushr.v14.i2.10.
7
Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review.人体临床研究中的药用蘑菇。第一部分。抗癌、肿瘤免疫和免疫调节活性：综述。
Int J Med Mushrooms. 2017;19(4):279-317. doi: 10.1615/IntJMedMushrooms.v19.i4.10.
8
A Review on Phytochemistry and Pharmacology of Medicinal as well as Poisonous Mushrooms.药用及有毒蘑菇的植物化学和药理学研究进展
Mini Rev Med Chem. 2018;18(13):1095-1109. doi: 10.2174/1389557517666170927144119.
9
Mycotherapy of cancer: an update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action.癌症的真菌疗法：真菌细胞毒性和抗肿瘤活性、生物活性成分及其作用的分子机制的最新研究进展。
Curr Top Med Chem. 2013;13(21):2791-806. doi: 10.2174/15680266113136660198.
10
Medicinal mushroom science: Current perspectives, advances, evidences, and challenges.药用蘑菇科学：当前的观点、进展、证据和挑战。
Biomed J. 2014 Nov-Dec;37(6):345-56. doi: 10.4103/2319-4170.138318.
引用本文的文献
1
Pleurotus Mushrooms in Nutrition and Health: Clinical and Preclinical Insights for Nutraceutical Development.平菇在营养与健康中的作用：营养保健品开发的临床与临床前见解
Compr Rev Food Sci Food Saf. 2025 Sep;24(5):e70279. doi: 10.1111/1541-4337.70279.
2
Ultrasound-assisted extraction of neuroprotective antioxidants from Ganoderma lucidum.超声辅助从灵芝中提取神经保护抗氧化剂
Ultrason Sonochem. 2025 Aug 25;121:107528. doi: 10.1016/j.ultsonch.2025.107528.
3
Antibacterial and Antifungal Potential of Hermetia illucens Hemolymph Contained-Peptides.黑水虻血淋巴中含有的肽的抗菌和抗真菌潜力。
Probiotics Antimicrob Proteins. 2025 Aug 7. doi: 10.1007/s12602-025-10697-x.
4
Valorization of various lignocellulosic wastes to Ganoderma lucidum (Curtis) P. Karst (Reishi Mushroom) cultivation and their FT-IR assessments.将各种木质纤维素废料用于灵芝（Curtis）P. Karst（灵芝蘑菇）栽培及其傅里叶变换红外光谱评估
PLoS One. 2025 Jul 22;20(7):e0328732. doi: 10.1371/journal.pone.0328732. eCollection 2025.
5
Harnessing the Nutritional Value, Therapeutic Applications, and Environmental Impact of Mushrooms.利用蘑菇的营养价值、治疗应用及环境影响。
Food Sci Nutr. 2025 Jul 15;13(7):e70611. doi: 10.1002/fsn3.70611. eCollection 2025 Jul.
6
Unveiling the role of erinacines in the neuroprotective effects of : a systematic review in preclinical models.揭示齿孔酸在[具体事物]神经保护作用中的角色：临床前模型的系统评价
Front Pharmacol. 2025 Jun 23;16:1582081. doi: 10.3389/fphar.2025.1582081. eCollection 2025.
7
Comparative study on the therapeutic potential of aqueous extracts from commercially cultivated Agaricus bisporus and Lentinula edodes in Sri Lanka: antioxidant, anticancer, antidiabetic, and antibacterial properties.斯里兰卡商业种植的双孢蘑菇和香菇水提取物治疗潜力的比较研究：抗氧化、抗癌、抗糖尿病和抗菌特性
BMC Complement Med Ther. 2025 Jul 3;25(1):233. doi: 10.1186/s12906-025-04984-x.
8
Unlocking the therapeutic potential of bioactive compounds in : a new frontier in natural medicine.挖掘生物活性化合物在……中的治疗潜力：天然药物的新前沿。 （注：原文中“in”后面缺少具体内容）
3 Biotech. 2025 Jul;15(7):203. doi: 10.1007/s13205-025-04353-y. Epub 2025 Jun 7.
9
Functional Foods Alleviate Behavioral Alterations and Improve GABAergic System Regulating TLR-4/NF-κB Axis in Valproic-Induced Autism.功能性食品可缓解丙戊酸诱导的自闭症中的行为改变并改善调节TLR-4/NF-κB轴的γ-氨基丁酸能系统
Brain Behav. 2025 Jun;15(6):e70591. doi: 10.1002/brb3.70591.
10
Enhancing the yield, fruiting body traits, and nutritional properties of five major edible fungi through the exploitation of ginger straw substrate.通过利用姜秸秆基质提高五种主要食用菌的产量、子实体性状和营养特性。
Front Nutr. 2025 May 16;12:1583716. doi: 10.3389/fnut.2025.1583716. eCollection 2025.
本文引用的文献
1
Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review.药用蘑菇在整合肿瘤学中的意义：一项叙述性综述
Front Pharmacol. 2020 Nov 11;11:580656. doi: 10.3389/fphar.2020.580656. eCollection 2020.
2
Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products.食用和药用蘑菇及其生物活性免疫调节产物的免疫调节作用。
J Fungi (Basel). 2020 Nov 8;6(4):269. doi: 10.3390/jof6040269.
3
Nephroprotective Effect of and Extracts and Carvedilol on Ethylene Glycol-Induced Urolithiasis: Roles of NF-κB, p53, Bcl-2, Bax and Bak.和提取物及卡维地洛对乙二醇诱导的尿石症的肾保护作用：NF-κB、p53、Bcl-2、Bax 和 Bak 的作用。
Biomolecules. 2020 Sep 14;10(9):1317. doi: 10.3390/biom10091317.
4
Ganoderic Acid D Protects Human Amniotic Mesenchymal Stem Cells against Oxidative Stress-Induced Senescence through the PERK/NRF2 Signaling Pathway.灵芝酸 D 通过 PERK/NRF2 信号通路保护人羊膜间充质干细胞抵抗氧化应激诱导的衰老。
Oxid Med Cell Longev. 2020 Jul 27;2020:8291413. doi: 10.1155/2020/8291413. eCollection 2020.
5
Examining the health effects and bioactive components in Agaricus bisporus mushrooms: a scoping review.研究双孢蘑菇的健康效应和生物活性成分：范围综述。
J Nutr Biochem. 2020 Oct;84:108453. doi: 10.1016/j.jnutbio.2020.108453. Epub 2020 Jun 13.
6
Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Mycelia Pilot Double-Blind Placebo-Controlled Study.富含海宝菌素A的菌丝体预防早期阿尔茨海默病：先导双盲安慰剂对照研究
Front Aging Neurosci. 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. eCollection 2020.
7
A mushroom diet reduced the risk of pregnancy-induced hypertension and macrosomia: a randomized clinical trial.蘑菇饮食可降低妊娠期高血压和巨大儿风险：一项随机临床试验。
Food Nutr Res. 2020 Jun 8;64. doi: 10.29219/fnr.v64.4451. eCollection 2020.
8
Efficacy of Pleuran (-Glucan from ) in the Management of Herpes Simplex Virus Type 1 Infection.普列蓝（来源于[具体来源]的β-葡聚糖）在单纯疱疹病毒1型感染管理中的疗效
Evid Based Complement Alternat Med. 2020 Apr 13;2020:8562309. doi: 10.1155/2020/8562309. eCollection 2020.
9
Antitumor, Anti-Inflammatory and Antiallergic Effects of Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, and : A Review of Preclinical and Clinical Studies.蘑菇提取物及相关药用担子菌的抗肿瘤、抗炎和抗过敏作用：临床前和临床研究综述。
Nutrients. 2020 May 8;12(5):1339. doi: 10.3390/nu12051339.
10
Therapeutic Potential of for Depressive Disorder.用于治疗抑郁症的潜力。
Int J Mol Sci. 2019 Dec 25;21(1):163. doi: 10.3390/ijms21010163.
Zotero 插件