Ligabue-Braun Rodrigo
Department of Pharmacosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil.
J Venom Anim Toxins Incl Trop Dis. 2020 Dec 14;26:e20200051. doi: 10.1590/1678-9199-JVATITD-2020-0051.
The relationship between slow loris ( spp.) venom (BGE protein) and the major cat allergen (Fel d 1) from domestic cat () is known for about two decades. Along this time, evidence was accumulated regarding convergences between them, including their almost identical mode of action.
Large-scale database mining for Fel d 1 and BGE proteins in Felidae and spp., alignment, phylogeny proposition and molecular modelling, associated with directed literature review were assessed.
Fel d 1 sequences for 28 non-domestic felids were identified, along with two additional loris BGE protein sequences. Dimer interfaces are less conserved among sequences, and the chain 1 shows more sequence similarity than chain 2. Post-translational modification similarities are highly probable.
Fel d 1 functions beyond allergy are discussed, considering the great conservation of felid orthologs of this protein. Reasons for toxicity being found only in domestic cats are proposed in the context of domestication. The combination of the literature review, genome-derived sequence data, and comparisons with the venomous primate slow loris may point to domestic cats as potentially poisonous mammals.
懒猴（属）毒液（BGE蛋白）与家猫（）的主要猫过敏原（Fel d 1）之间的关系已为人所知约二十年。在此期间，积累了关于它们之间趋同现象的证据，包括它们几乎相同的作用方式。
对猫科动物和懒猴属中的Fel d 1和BGE蛋白进行大规模数据库挖掘、比对、系统发育推断和分子建模，并结合定向文献综述进行评估。
鉴定出了28种非家猫科动物的Fel d 1序列，以及另外两种懒猴BGE蛋白序列。序列之间的二聚体界面保守性较低，链1比链2显示出更多的序列相似性。翻译后修饰相似性很可能存在。
考虑到该蛋白猫科直系同源物的高度保守性，讨论了Fel d 1在过敏之外的功能。在驯化背景下提出了仅在家猫中发现毒性的原因。文献综述、基因组衍生序列数据以及与有毒灵长类动物懒猴的比较相结合，可能表明家猫是潜在的有毒哺乳动物。
