新型金精酸抗生素。I. 筛选、分离、表征及生物学特性

New aureolic acid antibiotics. I. Screening, isolation, characterization and biological properties.

作者信息

Koenuma M, Uchida N, Yamaguchi K, Kawamura Y, Matsumoto K

机构信息

Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.

出版信息

J Antibiot (Tokyo). 1988 Jan;41(1):45-52. doi: 10.7164/antibiotics.41.45.

DOI:10.7164/antibiotics.41.45

PMID:3346192

Abstract

A new antibiotic complex was isolated from the fermentation broth of Streptomyces aburaviensis PA-39856. The individual factors, demethylolivomycins A, B and demethylchromomycins A2, A3 were separated and purified by preparative HLC. These antibiotics possess high activities against Gram-positive bacteria and P388 leukemia in mice.

摘要

从阿部拉链霉菌PA - 39856的发酵液中分离出一种新的抗生素复合物。通过制备型高效液相色谱法分离并纯化了其各个组分，即去甲基橄榄霉素A、B以及去甲基色霉素A2、A3。这些抗生素对革兰氏阳性菌和小鼠P388白血病具有高活性。