Laboratory of Imaging Biomarkers, Centre de Recherche sur l'Inflammation, Inserm UMR 1149, Université de Paris and AP-HP, Paris, France.
Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Methods Mol Biol. 2021;2216:383-402. doi: 10.1007/978-1-0716-0978-1_22.
The water proton longitudinal relaxation time, T, is a common and useful MR parameter in nephrology research. Here we provide three step-by-step T-mapping protocols suitable for different types of nephrology research. Firstly, we provide a single-slice 2D saturation recovery protocol suitable for studies of global pathology, where whole-kidney coverage is unnecessary. Secondly, we provide an inversion recovery type imaging protocol that may be optimized for specific kidney disease applications. Finally, we also provide imaging protocol for small animal kidney imaging in a clinical scanner.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concept and experimental procedure.
水质子纵向弛豫时间 T 是肾脏病学研究中常用且有用的磁共振参数。本文提供三种逐步 T 映射方案，适用于不同类型的肾脏病学研究。首先，我们提供一种适用于全局病理学研究的单层面 2D 饱和恢复方案，这种方案不需要整个肾脏的覆盖。其次，我们提供一种反转恢复类型的成像方案，该方案可能针对特定的肾脏疾病应用进行了优化。最后，我们还提供了一种在临床扫描仪中对小动物肾脏成像的成像方案。本章内容基于 COST 行动 PARENCHIMA 的工作，这是一个由欧洲科学技术合作组织（COST）资助的社区驱动网络，旨在提高肾脏 MRI 生物标志物的可重复性和标准化。该分析方案章节还辅以另外两章，分别描述了基本概念和实验程序。
