肾脏血流的动脉自旋标记 MRI 技术：实验方案与原理。
Renal Blood Flow Using Arterial Spin Labeling (ASL) MRI: Experimental Protocol and Principles.
机构信息
Queensland Brain Institute and Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia.
Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
出版信息
Methods Mol Biol. 2021;2216:443-453. doi: 10.1007/978-1-0716-0978-1_26.
A noninvasive, robust, and reproducible method to measure renal perfusion is important to understand the physiology of kidney. Arterial spin labeling (ASL) MRI technique labels the endogenous blood water as freely diffusible tracers to measure perfusion quantitatively without relying on exogenous contrast agent. Therefore, it alleviates the safety concern involving gadolinium chelates. To obtain quantitative tissue perfusion information is particularly relevant for multisite and longitudinal imaging of living subjects.This chapter is based upon work from the PARENCHIMA COST Action, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This experimental protocol chapter is complemented by two separate chapters describing the basic concept and data analysis.
一种无创、稳健且可重复的测量肾脏灌注的方法对于理解肾脏生理学非常重要。动脉自旋标记 (ASL) MRI 技术将内源性血液水标记为自由扩散示踪剂，无需依赖外源性造影剂即可定量测量灌注。因此，它减轻了涉及钆螯合物的安全问题。获得定量组织灌注信息对于活体多部位和纵向成像尤其相关。本章基于 PARENCHIMA COST 行动的工作，这是一个由欧洲科学技术合作组织（COST）计划资助的社区驱动网络，旨在提高肾脏 MRI 生物标志物的可重复性和标准化。本实验方案章节由另外两章补充说明，分别描述基本概念和数据分析。
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