Aziz Ayesha, Asif Muhammad, Ashraf Ghazala, Farooq Umer, Yang Qiaoli, Wang Shenqi
Advanced Biomaterials and Tissue Engineering Centre, School of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, PR China.
School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, PR China.
Curr Opin Colloid Interface Sci. 2021 Apr;52:101418. doi: 10.1016/j.cocis.2021.101418. Epub 2021 Jan 20.
In this ongoing theme of coronavirus disease 2019 (COVID-19) pandemic, highly sensitive analytical testing platforms are extremely necessary to detect RNA and antiviral antibodies. To limit the viral spread, prompt and precise diagnosis is crucial to facilitate treatment and ensure effective isolation. Accurate detection of antibodies (IgG and IgM) is imperative to understand the prevalence of in public and to inspect the proportion of immune individuals. In this review, we demonstrate and evaluate some tests that have been used commonly to detect . These include nucleic acid and serological tests for the detection of RNA and specific antibodies in infected people. Moreover, the vitality of biosensing technologies emphasizing on optical and electrochemical biosensors toward the detection of 2 has also been discussed here. The early diagnosis of COVID-19 based on detection of reactive oxygen species overproduction because of virus-induced dysfunctioning of lung cells has also been highlighted.
在2019冠状病毒病（COVID-19）大流行这一持续的主题下，高灵敏度分析检测平台对于检测RNA和抗病毒抗体极为必要。为了限制病毒传播，快速准确的诊断对于促进治疗和确保有效隔离至关重要。准确检测抗体（IgG和IgM）对于了解公众中的流行情况以及检查免疫个体的比例至关重要。在本综述中，我们展示并评估了一些常用于检测的测试。这些包括用于检测感染者中RNA和特定抗体的核酸和血清学检测。此外，本文还讨论了强调光学和电化学生物传感器的生物传感技术在检测方面的活力。基于检测因病毒诱导的肺细胞功能障碍而导致的活性氧过度产生对COVID-19进行早期诊断也得到了强调。
