Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo, Japan.
Sci Rep. 2021 Jan 26;11(1):2174. doi: 10.1038/s41598-021-81748-w.
A decrease in the elasticity of the ocular lens during aging is associated with loss of the accommodative ability of the eye, leading to presbyopia. Although near vision impairment is a social issue affecting the length of healthy life expectancy and productivity of elderly people, an effective treatment to improve near vision has not yet become available. Here we examined the effect of Enterococcus faecium WB2000, Lactobacillus pentosus TJ515, and resveratrol on lens elasticity in rats, where the stiffness of the ocular lens increases exponentially during the aging process. A combination of WB2000 and resveratrol improved lens elasticity not only in the long term but also with just short-term treatment. In addition, TJ515 decreased stiffness in the eye lens with long-term treatment. Therefore, the oral administration of WB2000 and resveratrol or TJ515 may be a potential approach for managing the progression of near vision impairment.
随着年龄的增长，眼球晶状体的弹性下降，与眼睛调节能力的丧失有关，导致远视。虽然近视力障碍是一个影响老年人预期健康寿命和生产力的社会问题，但还没有有效的治疗方法来改善近视力。在这里，我们研究了屎肠球菌 WB2000、戊糖片球菌 TJ515 和白藜芦醇对大鼠晶状体弹性的影响，在这个过程中，眼球晶状体的硬度呈指数级增长。WB2000 和白藜芦醇的组合不仅在长期而且在短期治疗中都能改善晶状体的弹性。此外，戊糖片球菌 TJ515 长期治疗可降低晶状体的硬度。因此，口服 WB2000 和白藜芦醇或戊糖片球菌 TJ515 可能是管理近视力障碍进展的一种潜在方法。
