College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Genes (Basel). 2021 Jan 27;12(2):180. doi: 10.3390/genes12020180.
The development of hair follicle in cashmere goats shows significant periodic change, as with mice and humans. However, for cashmere goat with double-coat, the periodic change may be due to other regulatory molecules and signal pathways. To understand the mechanism of periodic development of hair follicle, we performed a weighted gene coexpression network analysis (WGCNA) to mine key genes and establish an interaction network by utilizing the NCBI public dataset. Ten coexpression modules, including 7689 protein-coding genes, were constructed by WGCNA, six of which are considered to be significantly related to the development of the hair follicle cycle. A functional enrichment analysis for each model showed that they are closely related to ECM- receptor interaction, focal adhesion, PI3K-Akt signaling pathway, estrogen signaling pathway, and so on. Combined with the analysis of differential expressed genes, 12 hub genes from coexpression modules were selected as candidate markers, i.e., , , , , , , , , , , and , which might be applied to improve cashmere production.
绒山羊毛囊的发育呈现出明显的周期性变化，这与小鼠和人类的情况相似。然而，对于具有双层被毛的绒山羊，这种周期性变化可能是由于其他调节分子和信号通路所致。为了了解毛囊周期性发育的机制，我们利用 NCBI 公共数据集进行了加权基因共表达网络分析（WGCNA），以挖掘关键基因并建立相互作用网络。通过 WGCNA 构建了包含 7689 个蛋白质编码基因的 10 个共表达模块，其中 6 个模块被认为与毛囊周期的发育密切相关。对每个模型的功能富集分析表明，它们与细胞外基质-受体相互作用、粘着斑、PI3K-Akt 信号通路、雌激素信号通路等密切相关。结合差异表达基因分析，从共表达模块中选择了 12 个关键基因作为候选标记，即、、、、、、、、、和，它们可能被应用于提高羊绒产量。
