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甘草查尔酮 A 脂质体通过抑制炎症细胞因子的产生改善 UVB 诱导的红斑和皮肤硬化。

Glabridin Liposome Ameliorating UVB-Induced Erythema and Lethery Skin by Suppressing Inflammatory Cytokine Production.

机构信息

Hua An Tang Biotech Group Co., Ltd., Guangzhou 510000, P.R. China.

Guangdong He Ji Biotech Co., Ltd., Guangzhou 510000, P.R. China.

出版信息

J Microbiol Biotechnol. 2021 Apr 28;31(4):630-636. doi: 10.4014/jmb.2011.11006.

DOI:10.4014/jmb.2011.11006
PMID:33526759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9706034/
Abstract

Glabridin, a compound of the flavonoid, has shown outstanding skin-whitening and anti-aging properties, but its water insolubility limits its wide application. Therefore, glabridin liposome (GL) has been developed to improve its poor bioavailability, while there are few studies to evaluate its amelioration of UVB- induced photoaging. This study is performed to investigate the amelioration of GL against UVB- induced cutaneous photoaging. The prepared GL has a spheroidal morphology with an average diameter of 200 nm. The GL shows lower cytotoxicity than glabridin, but it has a more effective role in inhibition of melanin. Moreover, the application of GL can effectively relieve UV radiation induced erythema and leathery skin, associated with the down-regulated expression of inflammatory cytokines (TNF-α, IL-6 and IL-10). Taken together, these results demonstrate that GL has potentials as topical therapeutic agents against UVB radiation induced skin damage through inhibiting inflammation.

摘要

甘草查尔酮 A 是一种黄酮类化合物，具有出色的皮肤美白和抗衰老特性，但由于其不溶于水，限制了其广泛应用。因此，开发了甘草查尔酮 A 脂质体（GL）来提高其较差的生物利用度，但很少有研究评估其对 UVB 诱导的光老化的改善作用。本研究旨在探讨 GL 对 UVB 诱导的皮肤光老化的改善作用。制备的 GL 呈球形形态，平均直径为 200nm。GL 的细胞毒性低于甘草查尔酮 A，但对黑色素的抑制作用更有效。此外，GL 的应用可以有效缓解 UV 辐射引起的红斑和皮革样皮肤，这与炎症细胞因子（TNF-α、IL-6 和 IL-10）表达下调有关。综上所述，这些结果表明 GL 具有通过抑制炎症作为局部治疗剂对抗 UVB 辐射引起的皮肤损伤的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/9e0da6ee76a7/jmb-31-4-630-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/e9ef033ef4c5/jmb-31-4-630-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/d1cb92d930f7/jmb-31-4-630-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/6f1e339de8de/jmb-31-4-630-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/572417190366/jmb-31-4-630-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/c4344f69c46d/jmb-31-4-630-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/9e0da6ee76a7/jmb-31-4-630-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/e9ef033ef4c5/jmb-31-4-630-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/d1cb92d930f7/jmb-31-4-630-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/6f1e339de8de/jmb-31-4-630-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/572417190366/jmb-31-4-630-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/c4344f69c46d/jmb-31-4-630-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b30d/9706034/9e0da6ee76a7/jmb-31-4-630-f6.jpg

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2
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5
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