Yang Jung-Hwa, Choi Chang Kyun, Kim Hye-Yeon, Heo Young-Ran, Shin Min-Ho
Department of Food and Nutrition, Chonnam National University, Gwangju, Korea.
Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
Chonnam Med J. 2021 Jan;57(1):68-75. doi: 10.4068/cmj.2021.57.1.68. Epub 2021 Jan 25.
We investigated the association between alcohol drinking status and depressive symptoms in a representative sample of South Korean adults using data from the 2017 Korea Community Health Survey (KCHS), which included 216,771 participants (99,845 men and 116,926 women). Depression was defined as a Patient Health Questionnaire-9 score of ≥10. Multivariate logistic regression using sampling weights was used to assess the relationship between alcohol drinking status and depression after adjusting for potential confounders. Alcohol intake was nonlinearly associated with depression; the risk of depression was the lowest in men who were moderate drinkers and women who were light drinkers. In men, heavy drinkers (odds ratio [OR] 1.41, 95% confidence interval [CI] 1.19-1.67), light drinkers (OR 1.13, 95% CI 0.94-1.36), infrequent drinkers (OR 1.31, 95% CI 1.00-1.73), and lifetime abstainers (OR 1.38, 95% CI 1.09-1.75) were at a higher risk of depression than moderate drinkers. In women, moderate drinkers (OR 1.19, 95% CI 1.02-1.40) and heavy drinkers (OR 1.56, 95% CI 1.33-1.84) were at a higher risk of depression than light drinkers; however, infrequent drinkers and lifetime abstainers were not at a high risk of depression. In both men and women, former drinkers were at a higher risk of depression (OR 1.61, 95% CI 1.34-1.93 and OR 1.25, 95% CI 1.09-1.43, respectively). In conclusion, the association between alcohol drinking status and depression was nonlinear in both sexes. Further investigation of age- and sex-specific factors related to the association between alcohol use and depression is needed.
我们利用2017年韩国社区健康调查（KCHS）的数据，对韩国成年人的代表性样本中饮酒状况与抑郁症状之间的关联进行了调查。该调查包括216,771名参与者（99,845名男性和116,926名女性）。抑郁症被定义为患者健康问卷-9得分≥10。在调整潜在混杂因素后，使用抽样权重的多变量逻辑回归来评估饮酒状况与抑郁症之间的关系。酒精摄入量与抑郁症呈非线性关联；抑郁症风险在男性中度饮酒者和女性轻度饮酒者中最低。在男性中，重度饮酒者（优势比[OR]1.41，95%置信区间[CI]1.19-1.67）、轻度饮酒者（OR 1.13, 95% CI 0.94-1.36）、偶尔饮酒者（OR 1.31, 95% CI 1.00-1.73）和终生戒酒者（OR 1.38, 95% CI 1.09-1.75）患抑郁症风险高于中度饮酒者。在女性中，中度饮酒者（OR 1.19, 95% CI 1.02-1.40）和重度饮酒者（OR 1.56, 95% CI 1.33-1.84）患抑郁症风险高于轻度饮酒者；然而，偶尔饮酒者和终生戒酒者患抑郁症风险不高。在男性和女性中，既往饮酒者患抑郁症风险均较高（分别为OR 1.61, 95% CI 1.34-1.93和OR 1.25, 95% CI 1.09-1.43）。总之，饮酒状况与抑郁症之间的关联在两性中均呈非线性。需要进一步调查与饮酒和抑郁症关联相关的年龄和性别特异性因素。
