Faculty of Natural Sciences and Mathematics, University of Maribor, Koroška cesta 160, 2000, Maribor, Slovenia.
Faculty od Medicine, University of Maribor, Taborska ulica 8, 2000, Maribor, Slovenia.
Sci Rep. 2021 Feb 4;11(1):3093. doi: 10.1038/s41598-021-82770-8.
Social distancing is an effective strategy to mitigate the impact of infectious diseases. If sick or healthy, or both, predominantly socially distance, the epidemic curve flattens. Contact reductions may occur for different reasons during a pandemic including health-related mobility loss (severity of symptoms), duty of care for a member of a high-risk group, and forced quarantine. Other decisions to reduce contacts are of a more voluntary nature. In particular, sick people reduce contacts consciously to avoid infecting others, and healthy individuals reduce contacts in order to stay healthy. We use game theory to formalize the interaction of voluntary social distancing in a partially infected population. This improves the behavioral micro-foundations of epidemiological models, and predicts differential social distancing rates dependent on health status. The model's key predictions in terms of comparative statics are derived, which concern changes and interactions between social distancing behaviors of sick and healthy. We fit the relevant parameters for endogenous social distancing to an epidemiological model with evidence from influenza waves to provide a benchmark for an epidemic curve with endogenous social distancing. Our results suggest that spreading similar in peak and case numbers to what partial immobilization of the population produces, yet quicker to pass, could occur endogenously. Going forward, eventual social distancing orders and lockdown policies should be benchmarked against more realistic epidemic models that take endogenous social distancing into account, rather than be driven by static, and therefore unrealistic, estimates for social mixing that intrinsically overestimate spreading.
社交隔离是减轻传染病影响的有效策略。如果生病或健康,或者两者兼而有之,主要进行社交隔离,那么疫情曲线就会变得平缓。在大流行期间,接触减少可能出于不同的原因,包括与健康相关的流动性丧失(症状严重程度)、对高风险群体成员的关怀义务,以及强制隔离。其他减少接触的决定则更多是出于自愿。特别是,病人会有意识地减少接触以避免感染他人,而健康人则会减少接触以保持健康。我们使用博弈论来形式化部分感染人群中自愿社交隔离的相互作用。这改进了流行病学模型的行为微观基础,并预测了依赖于健康状况的不同社交隔离率。从比较静态的角度推导出了模型的关键预测,这些预测涉及病人和健康人社交隔离行为的变化和相互作用。我们根据流感波的证据,将内源性社交隔离的相关参数拟合到一个流行病学模型中,为具有内源性社交隔离的疫情曲线提供了一个基准。我们的结果表明,具有相似峰值和病例数的疫情,却能更快地过去,可能是内源性产生的。展望未来,最终的社交隔离命令和封锁政策应该以更现实的考虑到内源性社交隔离的流行病模型为基准,而不是以静态的、因此不现实的社交混合估计为基准,因为这些估计会过高地估计传播。