Daou Anis
Pharmaceutical Sciences Department, College of Pharmacy, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Vaccines (Basel). 2021 Feb 3;9(2):120. doi: 10.3390/vaccines9020120.
The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. This will help reduce the stress for millions of people around the globe, helping to restore worldwide normalcy. In this review, the analysis looks into how the new branch of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) came into the forefront of the world like a pandemic. This review will break down the details of what COVID-19 is, the viral family it belongs to and its background of how this family of viruses alters bodily functions by attacking vital human respiratory organs, the circulatory system, the central nervous system and the gastrointestinal tract. This review also looks at the process a new drug analogue undergoes, from (i) being a promising lead compound to (ii) being released into the market, from the drug development and discovery stage right through to FDA approval and aftermarket research. This review also addresses viable reasoning as to why the SARS-CoV-2 vaccine may have taken much less time than normal in order for it to be released for use.
新型冠状病毒（COVID-19）疫苗正在进行最后的分析和测试阶段。在我们即将取得潜在突破性疫苗的情况下，这是一项令人瞩目的成就。这将有助于减轻全球数百万人的压力，助力恢复全球正常状态。在这篇综述中，分析探讨了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）这一新分支是如何像大流行病一样成为全球关注焦点的。这篇综述将详细剖析COVID-19是什么、它所属的病毒家族以及该病毒家族如何通过攻击人体重要呼吸器官、循环系统、中枢神经系统和胃肠道来改变身体机能的背景情况。这篇综述还审视了一种新型药物类似物从（i）作为一种有前景的先导化合物到（ii）投放市场所经历的过程，即从药物研发和发现阶段一直到获得美国食品药品监督管理局（FDA）批准及上市后研究的过程。这篇综述还阐述了关于SARS-CoV-2疫苗为何可能比正常情况花费更少时间就能获批使用的合理推断。
