Center of Bioimmobilisation and Innovative Packaging Materials, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology Szczecin, Janickiego 35, 71-270 Szczecin, Poland.
Department of Microbiology and Biotechnology, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology, Szczecin, Nanotechnology Center for Education and Research, Piastów Avenue 45, 70-311 Szczecin, Poland.
Int J Mol Sci. 2021 Feb 9;22(4):1717. doi: 10.3390/ijms22041717.
The purpose of the study was to obtain an external coating based on nanoparticles of ZnO, carvacrol, and geraniol that could be active against viruses such as SARS-Co-V2. Additionally, the synergistic effect of the chosen substances in coatings was analyzed. The goal of the study was to measure the possible antibacterial activity of the coatings obtained. Testing antiviral activity with human pathogen viruses, such as SARS-Co-V2, requires immense safety measures. Bacteriophages such as phi 6 phage represent good surrogates for the study of airborne viruses. The results of the study indicated that the ZC1 and ZG1 coatings containing an increased amount of geraniol or carvacrol and a very small amount of nanoZnO were found to be active against Gram-positive and Gram-negative bacteria. It is also important that a synergistic effect between these active substances was noted. This explains why polyethylene (PE) films covered with the ZC1 or ZG1 coatings (as internal coatings) were found to be the best packaging materials to extend the quality and freshness of food products. The same coatings may be used as the external coatings with antiviral properties. The ZC1 and ZG1 coatings showed moderate activity against the phi 6 phage that has been selected as a surrogate for viruses such as coronaviruses. It can be assumed that coatings ZG1 and ZC1 will also be active against SARS-CoV-2 that is transmitted via respiratory droplets.
本研究的目的是获得一种基于 ZnO、香芹酚和香叶醇纳米粒子的外部涂层，该涂层能够对 SARS-CoV-2 等病毒发挥活性作用。此外，还分析了所选物质在涂层中的协同作用。本研究的目的是测量所获得的涂层的可能的抗菌活性。使用人类病原体病毒（如 SARS-CoV-2）进行抗病毒活性测试需要采取巨大的安全措施。噬菌体，如 phi 6 噬菌体，是研究空气传播病毒的良好替代品。研究结果表明，含有增加量的香芹酚或香叶醇和极少量纳米 ZnO 的 ZC1 和 ZG1 涂层对革兰氏阳性菌和革兰氏阴性菌具有活性。这些活性物质之间存在协同作用也很重要。这解释了为什么覆盖有 ZC1 或 ZG1 涂层（作为内部涂层）的聚乙烯（PE）薄膜被发现是延长食品质量和新鲜度的最佳包装材料。同样的涂层也可以用作具有抗病毒性能的外部涂层。ZC1 和 ZG1 涂层对已被选为冠状病毒等病毒替代物的 phi 6 噬菌体表现出中等活性。可以假设 ZG1 和 ZC1 涂层也将对通过呼吸道飞沫传播的 SARS-CoV-2 具有活性。
