Del Vecchio Alessandro, Tenore Gianluca, Luzi Maria Clotilde, Palaia Gaspare, Mohsen Ahmed, Pergolini Daniele, Romeo Umberto
Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.
Healthcare (Basel). 2021 Jan 29;9(2):134. doi: 10.3390/healthcare9020134.
The treatment of oral squamous cell carcinoma (OSCC) is particularly complex due to its aggressive behavior, location, the patient's age, and its spread at diagnosis. In recent years, photobiomodulation (PBM) has been introduced in different medical fields; however, its application, in patients suffering from OSCC for palliative support or to induce analgesia, has been hotly debated due to the possibility that the cell growth stimuli induced by PBM could lead to a worsening of the lesions. The aim of this study is to review the literature to observe the available data investigating the effect of PBM on cancer cells in vitro and in vivo. A review was conducted on the PubMed and Scopus databases. A total of twelve studies met the inclusion criteria and were therefore included for quality assessment and data extraction. The analysis showed that the clinical use of PBM is still only partially understood and is, therefore, controversial. Some authors stated that it could be contraindicated for clinical use in patients suffering from SCC, while others noted that it could have beneficial effects. According to the data that emerged from this review, it is possible to hypothesize that there are possibilities for PBM to play a beneficial role in treating cancer patients, but further evidence about its clinical efficacy and the identification of protocols and correct dosages is still needed.
口腔鳞状细胞癌（OSCC）的治疗因其侵袭性、位置、患者年龄以及诊断时的扩散情况而尤为复杂。近年来，光生物调节（PBM）已被引入不同的医学领域；然而，对于患有OSCC的患者，将其用于姑息支持或诱导镇痛，由于PBM诱导的细胞生长刺激可能导致病变恶化，其应用一直备受争议。本研究的目的是回顾文献，观察研究PBM在体外和体内对癌细胞作用的现有数据。对PubMed和Scopus数据库进行了综述。共有12项研究符合纳入标准，因此被纳入质量评估和数据提取。分析表明，PBM的临床应用仍仅部分被理解，因此存在争议。一些作者表示，它可能对患有鳞状细胞癌（SCC）的患者临床使用是禁忌的，而另一些人则指出它可能有有益效果。根据本次综述得出的数据，可以推测PBM在治疗癌症患者方面有可能发挥有益作用，但仍需要关于其临床疗效以及方案和正确剂量确定的进一步证据。
