Silva Juliana Dalcin Donini E, de Oliveira Rosana Rosseto, da Silva Mariana Teixeira, Carvalho Maria Dalva de Barros, Pedroso Raissa Bocchi, Pelloso Sandra Marisa
Health Sciences Department, Graduate Program in Health Science, State University of Maringá, Maringá, Brazil.
Health Sciences Department, Graduate Program in Nursing, State University of Maringá, Maringá, Brazil.
Front Oncol. 2021 Jan 25;10:569933. doi: 10.3389/fonc.2020.569933. eCollection 2020.
Malignant breast cancer is the leading cause of death by cancer in young women. The study aimed to determine if breast cancer mortality among young women has increased between the period from 1996 to 2017 in Brazil.
A time-series analysis of breast cancer mortality rate in young women (20-39 years old) was carried out. Mortality data, from 1996 to 2017, were collected from the Mortality Information System of the Health Ministry, and demographic data, from the Brazilian Institute of Geography and Statistics. Trends in mortality were performed by Joinpoint Regression, the spatial distribution of the mortality rate was done with the QGIZ Software version 2.18, and Spearman's correlation coefficient was used to correlate the mortality rates with the Human Development Index.
There was an increase in breast cancer mortality rates in young women in the majority of Brazilian states, with an upward trend in all regions. The correlation with the Municipal Human Development Index, income, and education had a significant impact on the mortality rate for women from 30-39 years old in both time frames evaluated and for women from 20-29 years old, only from 1996 to 2000.
The data obtained in the study, showed that even though the breast cancer mortality rate of young women is lower than women over 40 years old, it has been increasing in all regions of Brazil, mostly for women from 30-39 years old, suggesting that this group should be included in screening programs.
恶性乳腺癌是年轻女性癌症死亡的主要原因。本研究旨在确定1996年至2017年期间巴西年轻女性的乳腺癌死亡率是否有所上升。
对年轻女性(20 - 39岁)的乳腺癌死亡率进行了时间序列分析。1996年至2017年的死亡率数据来自卫生部的死亡率信息系统,人口数据来自巴西地理与统计研究所。死亡率趋势通过Joinpoint回归进行分析,死亡率的空间分布使用QGIZ软件2.18版本完成,Spearman相关系数用于将死亡率与人类发展指数进行关联。
巴西大多数州年轻女性的乳腺癌死亡率有所上升,所有地区均呈上升趋势。在评估的两个时间段内,与城市人类发展指数、收入和教育的相关性对30 - 39岁女性的死亡率有显著影响,而对于20 - 29岁女性,仅在1996年至2000年有显著影响。
该研究获得的数据表明,尽管年轻女性的乳腺癌死亡率低于40岁以上女性,但在巴西所有地区均呈上升趋势,主要是30 - 39岁的女性,这表明该群体应纳入筛查项目。