Chen Yijie, Yu Jingjing, Shi Lan, Han Shuyang, Chen Jun, Sheng Zhumei, Deng Miao, Jin Xuejing, Zhang Zhifen
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
School of Public Health, Hangzhou Normal University, Hangzhou, People's Republic of China.
J Inflamm Res. 2023 Jan 22;16:297-309. doi: 10.2147/JIR.S385220. eCollection 2023.
The aim of this research was to determine whether systemic inflammatory indicators, including aggregate index of systemic inflammation (AISI), neutrophils lymphocyte to platelet ratio (NLPR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), are related to bone mineral density (BMD) in perimenopausal and postmenopausal women.
One hundred and eighty-one perimenopausal and 390 postmenopausal women were enrolled in this cross-sectional study. Continuous variables by analysis of variance and Kruskal Wallis test for comparing the clinical characteristics. Linear regression analysis was conducted to investigate the associations between inflammatory indicators with BMD. The comparison between the subgroups was performed using the nonparametric test and the -test.
AISI, NLPR, SII, and SIRI quartile values were inversely associated with BMD in menopausal women ( = 0.021; = 0.047; < 0.001; < 0.001, respectively). After adjusting for confounding factors, four inflammatory indicators remained significantly associated with BMD (all for trend <0.001). Analysis according to menopausal status demonstrated that AISI, SII, and SIRI were significantly correlated with mean femoral neck BMD in postmenopausal women ( for trend = 0.015, 0.004, and 0.001), but not significantly associated with BMD in perimenopausal women ( for trend = 0.248, 0.054, and 0.352) after adjustment for covariates.
The quartile values of AISI, SII, and SIRI were inversely associated with BMD in postmenopausal women, following adjustment for individual variables, hormone profiles and glucolipid metabolism profiles. AISI, SII, and SIRI have potential to be important tools for screening and prevention of bone loss in menopausal women in future clinical practice.
本研究旨在确定全身炎症指标，包括全身炎症聚集指数（AISI）、中性粒细胞淋巴细胞与血小板比值（NLPR）、全身免疫炎症指数（SII）和全身炎症反应指数（SIRI），是否与围绝经期和绝经后女性的骨密度（BMD）相关。
181名围绝经期女性和390名绝经后女性参与了这项横断面研究。采用方差分析和Kruskal Wallis检验对连续变量进行分析，以比较临床特征。进行线性回归分析以研究炎症指标与骨密度之间的关联。使用非参数检验和t检验对亚组进行比较。
绝经后女性中，AISI、NLPR、SII和SIRI四分位数与骨密度呈负相关（分别为P = 0.021；P = 0.047；P < 0.001；P < 0.001）。在调整混杂因素后，四项炎症指标仍与骨密度显著相关（所有趋势P < 0.001）。根据绝经状态分析表明，绝经后女性中，AISI、SII和SIRI与平均股骨颈骨密度显著相关（趋势P = 0.015、0.004和0.001），但在调整协变量后，围绝经期女性中这些指标与骨密度无显著关联（趋势P = 0.248、0.054和0.352）。
在调整个体变量、激素谱和糖脂代谢谱后，绝经后女性中AISI、SII和SIRI的四分位数与骨密度呈负相关。AISI、SII和SIRI有可能成为未来临床实践中筛查和预防绝经后女性骨质流失的重要工具。
