Department of Pharmacology, Medical University of Silesia, Poland.
Inpatient Department of Radiation and Clinical Oncology, Maria Skłodowska-Curie Institute - Oncology Center, Gliwice Branch, Poland.
Pediatr Endocrinol Diabetes Metab. 2021;27(1):47-50. doi: 10.5114/pedm.2020.103058.
Type 1 diabetes is based on apoptosis, which leads to b-cell death. Factors triggering apoptosis processes are very diverse and currently not fully explained. The main role is attributed to genetic and environmental factors. Genetic studies have shown that the inherited propensity for type 1 diabetes is multi-genetic. Environmental factors modify the response to their own antigens, but are probably not necessary to start the autoaggression process. The effect of b-cell destruction is confirmed by the appearance of autoantibodies in the blood. The paper presents a review of the available literature regarding the self-destruction of pancreatic b-cells. The aim of the study was to draw attention to the extremely complicated and still unknown etiopathogenesis of type 1 diabetes by reviewing current literature related to the above topic. The goal is to acquire the knowledge necessary to develop and implement causal treatment for diabetes. At the moment, unfortunately, we do not have safe, innovative therapy methods in the field of diabetes prevention. Intensive research on the etiopathogenesis of type 1 diabetes is an extremely important field of medical research.
1 型糖尿病是基于细胞凋亡的，这导致了β细胞的死亡。触发细胞凋亡过程的因素非常多样化，目前尚未完全解释清楚。主要作用归因于遗传和环境因素。遗传研究表明，1 型糖尿病的遗传易感性是多基因的。环境因素改变了对自身抗原的反应，但可能不是启动自身免疫攻击过程所必需的。β细胞破坏的作用通过血液中出现自身抗体得到证实。本文综述了关于胰腺β细胞自身破坏的现有文献。本研究的目的是通过回顾与上述主题相关的当前文献，引起人们对 1 型糖尿病极其复杂且仍未知的病因发病机制的关注。目的是获得必要的知识，以便为糖尿病开发和实施因果治疗。不幸的是，目前我们在糖尿病预防领域还没有安全、创新的治疗方法。对 1 型糖尿病病因发病机制的深入研究是医学研究的一个极其重要的领域。
