Cason J, Ainley C C, Wolstencroft R A, Thompson R P
Gastrointestinal Laboratory, Rayne Institute, St Thomas's Hospital, London.
J Clin Pathol. 1988 Mar;41(3):241-6. doi: 10.1136/jcp.41.3.241.
The adherence of polymorphonuclear leucocytes (PMN) to nylon fibre was investigated in patients with Crohn's disease, ulcerative proctocolitis, and anorexia nervosa, and compared with changes of circulating PMNs, C reactive protein concentrations, erythrocyte sedimentation rates, and clinical assessment of disease activity. PMN adherence was in excess of the maximum value detected for healthy subjects in 14 of 25 patients with Crohn's disease and two of 10 with proctocolitis, but it was within the normal range for all eight with anorexia nervosa. High adherence in Crohn's disease, however, was not associated with quantitative or qualitative changes of PMN populations, absolute concentrations of C reactive protein, erythrocyte sedimentation rates, disease severity, drug regimens, malnutrition, or zinc deficiency. High PMN adherence in Crohn's disease may therefore reflect the activation in vivo of normal PMN by humoral factors.
对克罗恩病、溃疡性直肠结肠炎和神经性厌食症患者的多形核白细胞(PMN)与尼龙纤维的黏附性进行了研究,并与循环PMN、C反应蛋白浓度、红细胞沉降率以及疾病活动度的临床评估变化进行了比较。25例克罗恩病患者中有14例、10例直肠结肠炎患者中有2例的PMN黏附性超过了健康受试者检测到的最大值,但8例神经性厌食症患者的PMN黏附性均在正常范围内。然而,克罗恩病患者的高黏附性与PMN群体的数量或质量变化、C反应蛋白的绝对浓度、红细胞沉降率、疾病严重程度、药物治疗方案、营养不良或锌缺乏均无关。因此,克罗恩病患者的高PMN黏附性可能反映了体液因子在体内对正常PMN的激活作用。