先前的病毒症状和个体产妇影响了针对 SARS-CoV-2、HCoV-229E 和 HCoV-OC43 的 S1 和 S2 亚单位的人乳抗体交叉反应性的持续水平。
Previous viral symptoms and individual mothers influenced the leveled duration of human milk antibodies cross-reactive to S1 and S2 subunits from SARS-CoV-2, HCoV-229E, and HCoV-OC43.
机构信息
Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA.
出版信息
J Perinatol. 2021 May;41(5):952-960. doi: 10.1038/s41372-021-01001-0. Epub 2021 Mar 1.
OBJECTIVE
The influence of previous viral symptoms on the level and duration of human milk antibodies reactive to SARS-CoV-2, and common human coronaviruses (HCoVs) was investigated.
STUDY DESIGN
Antibodies reactive to S1 and S2 subunits from SARS-CoV-2, HCoV-OC43, and HCoV-229E were measured via ELISA in human milk samples collected from March to June 2020 in mothers with and without viral symptoms.
RESULTS
The presence of viral symptoms influenced the levels of SARS-CoV-2 S2-reactive SIgA/IgA and tended to influence SARS-CoV-2 S1 SIgA/IgA and S2-reactive SIgM/IgM in human milk but did not relate to IgG. HCoV-229E S1 + S2-reactive SIgA/IgA and SIgM/IgM, as well as HCoV-OC43 S1 + S2-reactive IgG were related to the symptoms. The duration of antibody levels in human milk in mothers with viral symptoms varied between 3 and 4 months post maternal report of viral symptoms.
CONCLUSION
Previous viral symptoms and individual mothers may change the antibody cross-reactive levels to SARS-CoV-2 and HCoVs in human milk.
目的
研究先前的病毒症状对人乳中针对 SARS-CoV-2 和常见人类冠状病毒（HCoV）的人乳抗体水平和持续时间的影响。
研究设计
通过 ELISA 检测 2020 年 3 月至 6 月期间采集的来自有和无症状的母亲的人乳样本中针对 SARS-CoV-2 的 S1 和 S2 亚单位、HCoV-OC43 和 HCoV-229E 的抗体反应性。
结果
病毒症状的存在影响了人乳中 SARS-CoV-2 S2 反应性 SIgA/IgA 和 SARS-CoV-2 S1 SIgA/IgA 和 S2 反应性 SIgM/IgM 的水平，但与 IgG 无关。HCoV-229E S1+S2 反应性 SIgA/IgA 和 SIgM/IgM 以及 HCoV-OC43 S1+S2 反应性 IgG 与症状有关。有病毒症状的母亲的人乳中抗体水平的持续时间在母亲报告病毒症状后 3 至 4 个月之间有所不同。
结论
先前的病毒症状和个体母亲可能会改变人乳中针对 SARS-CoV-2 和 HCoVs 的抗体交叉反应性水平。
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