代谢-蛋氨酸与染色质结构的表观基因组关联。
Epigenomic links from metabolism-methionine and chromatin architecture.
机构信息
School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.
出版信息
Curr Opin Chem Biol. 2021 Aug;63:11-18. doi: 10.1016/j.cbpa.2021.01.011. Epub 2021 Mar 2.
Abstract
Chromatin and associated epigenetic marks provide important platforms for gene regulation in response to metabolic changes associated with environmental exposures, including physiological stress, nutritional deprivation, and starvation. Numerous studies have shown that fluctuations of key metabolites can influence chromatin modifications, but their effects on chromatin structure (e.g. chromatin compaction, nucleosome arrangement, and chromatin loops) and how they appropriately deposit specific chemical modification on chromatin are largely unknown. Here, focusing on methionine metabolism, we discuss recent developments of metabolic effects on chromatin modifications and structure, as well as consequences on gene regulation.
摘要
染色质和相关的表观遗传标记为基因调控提供了重要的平台，以响应与环境暴露相关的代谢变化，包括生理应激、营养剥夺和饥饿。许多研究表明，关键代谢物的波动会影响染色质修饰，但它们对染色质结构（如染色质紧缩、核小体排列和染色质环）的影响以及它们如何在染色质上适当沉积特定的化学修饰在很大程度上尚不清楚。在这里，我们重点讨论蛋氨酸代谢，讨论代谢物对染色质修饰和结构的影响的最新进展，以及对基因调控的影响。
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