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揭示褐藻的皮肤病学潜力

Unravelling the Dermatological Potential of the Brown Seaweed .

作者信息

Susano Patrícia, Silva Joana, Alves Celso, Martins Alice, Gaspar Helena, Pinteus Susete, Mouga Teresa, Goettert Márcia Ines, Petrovski Željko, Branco Luís B, Pedrosa Rui

机构信息

MARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal.

BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, 1749-016 Lisboa, Portugal.

出版信息

Mar Drugs. 2021 Feb 28;19(3):135. doi: 10.3390/md19030135.

DOI:10.3390/md19030135
PMID:33671016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7997182/
Abstract

The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed The antioxidant, anti-enzymatic, antimicrobial, photoprotective and anti-inflammatory properties of five fractions (F1-F5) were evaluated. The ethyl acetate fraction (F3) demonstrated the most promising results, with the best ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC of 140.1 µg/mL) and the capacity to reduce reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells, revealing its antioxidant and photoprotective potential. This fraction also exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, elastase and tyrosinase (IC of 7.2, 4.8 and 85.9 µg/mL, respectively). Moreover, F3 showed anti-inflammatory potential, reducing TNF-α and IL-6 release induced by LPS treatment in RAW 264.7 cells. These bioactivities may be related to the presence of phenolic compounds, such as phlorotannins, as demonstrated by NMR analysis. The results highlight the potential of as a source of bioactive ingredients for further dermatological applications.

摘要

人们对保持年轻外表和健康肌肤的兴趣与日俱增，推动了护肤品行业的发展。这一点，再加上对合成产品安全性的日益关注，增加了对新型、更安全天然成分的需求。因此，本研究的目的是评估棕色海藻的皮肤科应用潜力。对五个组分（F1 - F5）的抗氧化、抗酶、抗菌、光保护和抗炎特性进行了评估。乙酸乙酯组分（F3）显示出最有前景的结果，具有清除2,2 - 二苯基 - 1 - 苦基肼（DPPH）自由基的最佳能力（半数有效浓度为140.1 µg/mL），以及降低3T3细胞中由UVA和UVB辐射促进的活性氧（ROS）生成的能力，揭示了其抗氧化和光保护潜力。该组分还表现出最高的抗酶能力，分别抑制胶原酶、弹性蛋白酶和酪氨酸酶的活性（半数抑制浓度分别为7.2、4.8和85.9 µg/mL）。此外，F3显示出抗炎潜力，减少了RAW 264.7细胞中脂多糖处理诱导的TNF-α和IL-6释放。如NMR分析所示，这些生物活性可能与酚类化合物（如褐藻多酚）的存在有关。结果突出了[棕色海藻名称未给出]作为进一步皮肤科应用生物活性成分来源的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/431c2b900e19/marinedrugs-19-00135-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/dce3d176fcbb/marinedrugs-19-00135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/57f7c777be45/marinedrugs-19-00135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/1f0e6cfd3f5e/marinedrugs-19-00135-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/1e447a583f16/marinedrugs-19-00135-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/a29558ccc01b/marinedrugs-19-00135-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/b788f50311f2/marinedrugs-19-00135-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/1eec935eb7d1/marinedrugs-19-00135-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/431c2b900e19/marinedrugs-19-00135-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/dce3d176fcbb/marinedrugs-19-00135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/57f7c777be45/marinedrugs-19-00135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/1f0e6cfd3f5e/marinedrugs-19-00135-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/1e447a583f16/marinedrugs-19-00135-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/a29558ccc01b/marinedrugs-19-00135-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/b788f50311f2/marinedrugs-19-00135-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/1eec935eb7d1/marinedrugs-19-00135-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a3/7997182/431c2b900e19/marinedrugs-19-00135-g008.jpg

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