Institute of Solid State Physics of Russian Academy of Science, 142432 Chernogolovka, Russia.
Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.
Int J Mol Sci. 2021 Feb 12;22(4):1842. doi: 10.3390/ijms22041842.
Development of sensitive techniques for rapid detection of viruses is on a high demand. Surface-enhanced Raman spectroscopy (SERS) is an appropriate tool for new techniques due to its high sensitivity. DNA aptamers are short structured oligonucleotides that can provide specificity for SERS biosensors. Existing SERS-based aptasensors for rapid virus detection had several disadvantages. Some of them lacked possibility of quantitative determination, while others had sophisticated and expensive implementation. In this paper, we provide a new approach that combines rapid specific detection and the possibility of quantitative determination of viruses using the example of influenza A virus.
快速检测病毒的敏感技术的发展需求很高。表面增强拉曼光谱（SERS）是一种合适的新技术工具，因为它具有很高的灵敏度。DNA 适体是短链结构的寡核苷酸，可以为 SERS 生物传感器提供特异性。现有的基于 SERS 的快速病毒检测适体传感器有几个缺点。其中一些缺乏定量测定的可能性，而另一些则具有复杂且昂贵的实现方式。在本文中，我们以甲型流感病毒为例，提供了一种新的方法，该方法结合了快速特异性检测和病毒定量测定的可能性。
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