Xu Haoming, Ou Zhitao, Zhou Yongjian, Li Yingfei, Huang Hongli, Zhao Hailan, Xu Jing, Luo Meijuan, Zhou Youlian, Nie Yuqiang
Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China.
Department of Internal Medicine, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong 510180, P.R. China.
Exp Ther Med. 2021 Apr;21(4):391. doi: 10.3892/etm.2021.9822. Epub 2021 Feb 24.
Acquired immune deficiency syndrome, caused by the human immunodeficiency virus (HIV), has been associated with intestinal dysbiosis, which includes an increase in the number of mucosa-associated pathobionts. In the present study, the intestinal mucosal microbiota patterns of HIV-infected patients were compared with those of healthy individuals in a population from Guangzhou, China. The gut microbiota of intestinal mucosal samples from 12 patients with HIV (transmission routes included sex and intravenous drug abuse) was compared with that of 12 healthy age- and sex-matched controls. Gut microbial communities were profiled via sequencing of the bacterial 16S ribosomal RNA genes. Dysbiosis in HIV-infected individuals was characterized by decreased α-diversity, decreased levels of Firmicutes and increased levels of Proteobacteria. Furthermore, low mean counts of , , , and , and high mean counts of and bacteria, were indicated to be HIV-associated mucosal bacterial alterations. The relative abundance of and was significantly decreased, while that of and was significantly increased in patients with sexually transmitted HIV-infection compared with healthy controls. Alterations of the gut microbiota during HIV infection were also indicated to be associated with the route of HIV transmission. Certain bacteria may be potential biomarkers for HIV infection in patients from Guangzhou, China.
获得性免疫缺陷综合征由人类免疫缺陷病毒（HIV）引起，与肠道生态失调有关，其中包括黏膜相关致病共生菌数量的增加。在本研究中，在中国广州的人群中，对HIV感染患者的肠道黏膜微生物群模式与健康个体进行了比较。将12例HIV患者（传播途径包括性传播和静脉注射吸毒）肠道黏膜样本的肠道微生物群与12例年龄和性别匹配的健康对照者的进行了比较。通过对细菌16S核糖体RNA基因进行测序来分析肠道微生物群落。HIV感染个体的生态失调表现为α多样性降低、厚壁菌门水平降低和变形菌门水平升高。此外， 、 、 、 和 的平均计数较低，而 和 细菌的平均计数较高，被表明是与HIV相关的黏膜细菌改变。与健康对照相比，性传播HIV感染患者中 和 的相对丰度显著降低，而 和 的相对丰度显著增加。HIV感染期间肠道微生物群的改变也被表明与HIV传播途径有关。某些细菌可能是中国广州患者HIV感染的潜在生物标志物。
