He Yujing, Wu Na
Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, People' s Republic of China.
Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
Diabetes Metab Syndr Obes. 2021 Mar 3;14:983-990. doi: 10.2147/DMSO.S295737. eCollection 2021.
Gestational diabetes mellitus (GDM) is the onset or first recognition of diabetes during pregnancy in women with normal glucose metabolism or potentially impaired glucose tolerance before pregnancy. Studies have shown that vascular endothelial cells (VECs) are an important target organ of insulin, which is injured by multiple factors in the case of GDM, thereby leading to worsened insulin resistance (IR) and the further development of GDM. When VECs are abnormal, there will be changes in the content of a variety of cell markers, which may be helpful for the clinical prediction and diagnosis of GDM. This study attempted to investigate the mechanism and markers of VECs injury in GDM patients.
妊娠期糖尿病（GDM）是指孕期首次发生或被识别的糖尿病，这些孕妇在孕前糖代谢正常或糖耐量可能受损。研究表明，血管内皮细胞（VECs）是胰岛素的重要靶器官，在GDM情况下会受到多种因素的损伤，从而导致胰岛素抵抗（IR）恶化及GDM的进一步发展。当VECs异常时，多种细胞标志物的含量会发生变化，这可能有助于GDM的临床预测和诊断。本研究试图探讨GDM患者VECs损伤的机制及标志物。
