Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine Street, Baltimore, Maryland, 21201, USA.
Department of Biomedical Engineering, University of Miami, 1251 Memorial Drive, Coral Gables, Florida, 33156, USA.
AAPS PharmSciTech. 2021 Mar 12;22(3):101. doi: 10.1208/s12249-021-01975-2.
There is an increasing need to develop improved and non-invasive strategies to treat spinal cord injury (SCI). Nanoparticles (NPs) are an enabling technology to improve drug delivery, modulate inflammatory responses, and restore functional responses following SCI. However, the complex pathophysiology associated with SCI presents several distinct challenges that must be overcome for sufficient NP drug delivery to the spinal cord. The objective of this mini-review is to highlight the physiological challenges and cell types available for modulation and discuss several promising advancements using NPs to improve SCI treatment. We will focus our discussion on recent innovative approaches in NP drug delivery and how the implementation of multifactorial approaches to address the proinflammatory and complex immune dysfunction in SCI offers significant potential to improve outcomes in SCI.
脊髓损伤 (SCI) 的治疗需要开发改进的、非侵入性的策略，这一点变得愈发重要。纳米颗粒 (NPs) 是一种能够改善药物输送、调节炎症反应并恢复 SCI 后功能反应的技术。然而，SCI 相关的复杂病理生理学提出了几个需要克服的明显挑战，以便将足够的 NP 药物输送到脊髓。本篇迷你综述的目的是强调与 SCI 相关的生理挑战和可调节的细胞类型，并讨论使用 NPs 改善 SCI 治疗的几种有前途的进展。我们将集中讨论 NP 药物输送的最新创新方法，以及实施多因素方法来解决 SCI 中的促炎和复杂免疫功能障碍将如何为改善 SCI 结果提供巨大潜力。
