College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China; dongsheng, Email:
Pharmazie. 2021 Feb 25;76(2):55-60. doi: 10.1691/ph.2021.0958.
Ferulic acid, a hydroxyl derivative extracted from plants, is abundant in free state in seeds and leaves, or covalently linked with cell wall polysaccharides, lignin and different polymers. It has various pharmacological activities, including antioxidant and anti-inflammatory effects, regulates immunity, protects the cardiovascular system, and contributes to the prevention of tumors and diabetes. The protective effect on cardiovascular system is the most valuable one in view of clinical application. Here, we are reviewing the research progress concerning the pharmacological effects of ferulic acid and its derivatives on cardiovascular diseases in the past five years, mainly focusing on mechanisms of action and clinical application. This should provide guidance for clinical applications of ferulic acid and its derivatives in the treatment of cardiovascular diseases.
阿魏酸是一种从植物中提取的羟基衍生物，在种子和叶子中以游离态大量存在，或通过共价键与细胞壁多糖、木质素和不同的聚合物结合。它具有多种药理活性，包括抗氧化和抗炎作用，调节免疫，保护心血管系统，并有助于预防肿瘤和糖尿病。就临床应用而言，对心血管系统的保护作用是最有价值的。在这里，我们综述了过去五年中阿魏酸及其衍生物对心血管疾病的药理作用的研究进展，主要集中在作用机制和临床应用上。这应该为阿魏酸及其衍生物在治疗心血管疾病中的临床应用提供指导。
