Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
Institute for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
ACS Biomater Sci Eng. 2021 Sep 13;7(9):4128-4135. doi: 10.1021/acsbiomaterials.0c01801. Epub 2021 Mar 16.
When embedded into a three-dimensional (3D) matrix, cancer stem cells (or cancer-initiating cells) can grow into self-organizing organotypic structures called tumor organoids. During organoid formation, the matrix not only provides structural support but also delivers biochemical signals. Although increasing evidence indicates that the extracellular matrix (ECM) is an essential component of the tumor microenvironment during tumor development and progression, the influence of the ECM on organoid formation has been largely ignored; the ECM has only recently been recognized to play a role in the regulation of cancer cell phenotypes. We reviewed ECM-based hydrogels to tailoring tumor organoids and highlight the potential role of the ECM in the development of recapitulating malignant/invasive tumor organoids with enhanced capacity for in vitro representation of ECM-regulated tumor progression.
当嵌入到三维 (3D) 基质中时，癌症干细胞（或起始癌细胞）可以生长成称为肿瘤类器官的自组织器官样结构。在类器官形成过程中，基质不仅提供结构支撑，还传递生化信号。尽管越来越多的证据表明细胞外基质 (ECM) 是肿瘤发展和进展过程中肿瘤微环境的重要组成部分，但 ECM 对类器官形成的影响在很大程度上被忽视了；直到最近才认识到 ECM 在调节癌细胞表型方面发挥作用。我们综述了基于细胞外基质的水凝胶来定制肿瘤类器官，并强调了 ECM 在开发具有增强体外再现 ECM 调节的肿瘤进展能力的模拟恶性/侵袭性肿瘤类器官中的潜在作用。
