Meshref Mostafa, A Alshammari Hessa, Khairat Shiamaa M, Khan Roohi, Khan Imran
Neurology, Al-Azhar University, Cairo, EGY.
Internal Medicine, King Khaled Hospital, Hail, SAU.
Cureus. 2021 Feb 3;13(2):e13096. doi: 10.7759/cureus.13096.
COVID-19 has become a pandemic. It affects multiple systems of the body including the nervous system. It invades the nervous systems through multiple routes - either olfactory tract, bloodstream (by binding to endothelial receptors) or via ACE-2 receptors in the brain. We report a case of Guillain-Barré syndrome (GBS) variant (acute motor axonal neuropathy (AMAN type)) associated with COVID-19 infection with positive polymerase chain reaction (PCR) test for COVID-19 and positive contact history with infected family member. GBS and its variants like AMAN can occur due to COVID-19 infection through its immune-mediated effects. Diagnosis of GBS should depend on the clinical and supportive criteria. The treatment should be started early to prevent progression and disease co-morbidities.
新型冠状病毒肺炎已成为大流行病。它会影响身体的多个系统，包括神经系统。它通过多种途径侵入神经系统——要么通过嗅觉神经束，要么通过血液（通过与内皮受体结合），或者通过大脑中的血管紧张素转换酶2（ACE-2）受体。我们报告了一例与新型冠状病毒肺炎感染相关的格林-巴利综合征（GBS）变异型（急性运动轴索性神经病（AMAN型）），该患者新型冠状病毒肺炎聚合酶链反应（PCR）检测呈阳性，且有与感染家庭成员的密切接触史。GBS及其变异型如AMAN可因新型冠状病毒肺炎感染通过其免疫介导作用而发生。GBS的诊断应取决于临床和支持性标准。应尽早开始治疗，以防止病情进展和疾病合并症。
