Shi Jian, Duncan Brittany, Kuang Xuyuan
The Third Xiangya Hospital, Changsha, China.
Weill Medical College, New York, USA.
Clin Med (Lond). 2021 Mar;21(2):e223-e227. doi: 10.7861/clinmed.2020-0370.
Hydrogen therapy is a very promising treatment against several diseases due to its mild attributes, high affinity and inherent biosafety. However, there is little elaboration about current hydrogen treatment in liver diseases. This article introduces the administration of hydrogen and mechanisms of hydrogen therapy , including modulating reactive oxygen species, apoptosis and autophagy, and inflammation, affecting mitochondria, as well as protein transporters. The major focus is clinical hydrogen use and related mechanisms in liver dysfunction or diseases, including non-alcoholic fatty liver disease, hepatitis B, liver dysfunction caused by liver tumour and colorectal tumour chemotherapy. Further, the article reveals hydrogen application in liver protection. Finally, the article discusses the current and future challenges of hydrogen therapy in liver diseases, aiming to improve knowledge of hydrogen therapy and provide some insights into this burgeoning field.
氢疗法因其温和的特性、高亲和力和内在的生物安全性，是一种非常有前景的针对多种疾病的治疗方法。然而，目前关于氢疗法在肝脏疾病中的应用阐述较少。本文介绍了氢的给药方式以及氢疗法的作用机制，包括调节活性氧、细胞凋亡和自噬、炎症，影响线粒体以及蛋白质转运体。主要关注点是氢在肝功能障碍或疾病中的临床应用及相关机制，包括非酒精性脂肪性肝病、乙型肝炎、肝肿瘤和结直肠肿瘤化疗引起的肝功能障碍。此外，本文还揭示了氢在肝脏保护中的应用。最后，本文讨论了氢疗法在肝脏疾病中当前和未来面临的挑战，旨在增进对氢疗法的了解，并为这个新兴领域提供一些见解。
