Xue Xunwen, Ali Yasser F, Luo Wanrong, Liu Caorui, Zhou Guangming, Liu Ning-Ang
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Academy of Space Life Sciences, Soochow University, Suzhou, China.
Front Physiol. 2021 Mar 9;12:643943. doi: 10.3389/fphys.2021.643943. eCollection 2021.
The intrinsic earth magnetic field (geomagnetic field, GMF) provides an essential environmental condition for most living organisms to adapt the solar cycle by rhythmically synchronizing physiological and behavioral processes. However, hypomagnetic field (HMF) of outer space, the Moon, and the Mars differs much from GMF, which poses a critical problem to astronauts during long-term interplanetary missions. Multiple experimental works have been devoted to the HMF effects on circadian rhythm and found that HMF perturbs circadian rhythms and profoundly contributes to health problems such as sleep disorders, altered metabolic as well as neurological diseases. By systemizing the latest progress on interdisciplinary cooperation between magnetobiology and chronobiology, this review sheds light on the health effects of HMF on circadian rhythms by elaborating the underlying circadian clock machinery and molecular processes.
地球固有磁场（地磁场，GMF）为大多数生物通过有节奏地同步生理和行为过程来适应太阳周期提供了必要的环境条件。然而，外层空间、月球和火星的低磁场（HMF）与地磁场有很大不同，这给长期行星际任务中的宇航员带来了一个关键问题。多项实验研究致力于探讨HMF对昼夜节律的影响，发现HMF会扰乱昼夜节律，并严重导致诸如睡眠障碍、代谢改变以及神经疾病等健康问题。通过系统总结磁生物学和生物钟学跨学科合作的最新进展，本综述通过阐述潜在的生物钟机制和分子过程，揭示了HMF对昼夜节律的健康影响。
