Department of Pharmaceutical Technology, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
Mar Drugs. 2021 Mar 8;19(3):145. doi: 10.3390/md19030145.
There are several reviews that separately cover different aspects of fish gelatin including its preparation, characteristics, modifications, and applications. Its packaging application in food industry is extensively covered but other applications are not covered or covered alongside with those of collagen. This review is comprehensive, specific to fish gelatin/hydrolysate and cites recent research. It covers cosmetic applications, intrinsic activities, and biomedical applications in wound dressing and wound healing, gene therapy, tissue engineering, implants, and bone substitutes. It also covers its pharmaceutical applications including manufacturing of capsules, coating of microparticles/oils, coating of tablets, stabilization of emulsions and drug delivery (microspheres, nanospheres, scaffolds, microneedles, and hydrogels). The main outcomes are that fish gelatin is immunologically safe, protects from the possibility of transmission of bovine spongiform encephalopathy and foot and mouth diseases, has an economic and environmental benefits, and may be suitable for those that practice religious-based food restrictions, i.e., people of Muslim, Jewish and Hindu faiths. It has unique rheological properties, making it more suitable for certain applications than mammalian gelatins. It can be easily modified to enhance its mechanical properties. However, extensive research is still needed to characterize gelatin hydrolysates, elucidate the Structure Activity Relationship (SAR), and formulate them into dosage forms. Additionally, expansion into cosmetic applications and drug delivery is needed.
有几篇综述分别涵盖了鱼明胶的不同方面，包括其制备、特性、修饰和应用。其在食品工业中的包装应用得到了广泛的报道，但其他应用并未涵盖或与胶原蛋白的应用一起涵盖。这篇综述是全面的，专门针对鱼明胶/水解物，并引用了最近的研究。它涵盖了化妆品应用、内在活性以及在创伤敷料和伤口愈合、基因治疗、组织工程、植入物和骨替代物中的生物医学应用。它还涵盖了其在制药方面的应用，包括胶囊制造、微球/油的包衣、片剂包衣、乳液的稳定化和药物传递（微球、纳米球、支架、微针和水凝胶）。主要结果是鱼明胶具有免疫安全性，可防止牛海绵状脑病和口蹄疫传播的可能性，具有经济和环境效益，并且可能适合那些遵守基于宗教的食物限制的人，即穆斯林、犹太人和印度教徒。它具有独特的流变性能，使其比哺乳动物明胶更适合某些应用。它可以很容易地进行修饰以增强其机械性能。然而，仍需要进行广泛的研究来表征明胶水解物，阐明结构-活性关系（SAR），并将其制成剂型。此外，还需要扩展到化妆品应用和药物传递领域。
