Ren Teng, Gan Jing, Zhou Liping, Chen Hao
Marine College, Shandong University, Wenhua West Road, Gao Strict, Weihai 264209, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Polymers (Basel). 2020 Aug 2;12(8):1729. doi: 10.3390/polym12081729.
We developed the interpenetrating double network composite hydrogel based on poly (vinyl alcohol) (PVA) and fish gelatin (FG) via thermal treatment and repeated freeze-thawing. A function of salicylic acid was incorporated into the hydrogel to improve its antibacterial properties. The color values, water contents, water evaporation rate, and swelling behavior were investigated. The drug-loading performance of the composite hydrogel was demonstrated by loading salicylic acid in various hydrogel systems. Moreover, the cumulative dissolution percentage of salicylic acid and the antibacterial activity of composite hydrogel were carried out. The results revealed that as FG concentration increased from 0% to 3.75% (/), gels changed from white to slight yellow and the swelling ratio increased from 54% to 83% (within 8 h). The presence of FG decreased the water content of gels which ranged from 86% to 89% and also decreased water evaporation rate. All gels presented the swelling index within 0.5-1.0, indicating a non-Fickian diffusion mechanism. The drug sustained dissolution behavior of pure PVA and composite hydrogel showed the same trend. Besides, the presence of the obvious bacteriostatic zones means that drug-loaded composite hydrogels have an effective antibacterial property. These results demonstrated that PVA/FG-based interpenetrating hydrogel is an appropriate biomaterial for drug-carrying wound dressing application.
我们通过热处理和反复冻融，制备了基于聚乙烯醇（PVA）和鱼明胶（FG）的互穿双网络复合水凝胶。将水杨酸功能基团引入水凝胶以改善其抗菌性能。研究了其颜色值、含水量、水分蒸发速率和溶胀行为。通过在不同水凝胶体系中负载水杨酸，展示了复合水凝胶的载药性能。此外，还测定了水杨酸的累积溶出百分比和复合水凝胶的抗菌活性。结果表明，随着FG浓度从0%增加到3.75%（/），凝胶颜色从白色变为浅黄色，溶胀率在8小时内从54%增加到83%。FG的存在降低了凝胶的含水量，含水量范围为86%至89%，同时也降低了水分蒸发速率。所有凝胶的溶胀指数在0.5 - 1.0之间，表明其为非菲克扩散机制。纯PVA和复合水凝胶的药物持续溶出行为呈现相同趋势。此外，明显的抑菌圈表明载药复合水凝胶具有有效的抗菌性能。这些结果表明，基于PVA/FG的互穿水凝胶是一种适用于载药伤口敷料应用的生物材料。
