Nie Penghui, Wang Mengqi, Zhao Yu, Liu Shanji, Chen Ling, Xu Hengyi
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Nanomaterials (Basel). 2021 Mar 21;11(3):803. doi: 10.3390/nano11030803.
The potential toxicity of titanium dioxide nanoparticles (TiO NPs) to mammals has become a widespread concern. Young individuals exposed to TiO NPs have a higher risk than adults. In this study, the protective effects of GG (LGG) on liver toxicity in young rats induced by TiO NPs were explored. Results show that the four-week-old rats that underwent LGG after the oral intake of TiO NPs could prevent weight loss, reduce hematological indicators (WBC and NEUT) and serum biochemical indicators (AST, ALT, AST/ALT, and ALP). Moreover, it alleviated the pathological damage of the liver (as indicated by the disordered hepatocytes, more eosinophilic, ballooning degeneration, and accompany with blood cells), but it did not reduce the Ti contents in the liver. In addition, RT-qPCR results indicated that LGG restored the expression of anti-oxidative stress-related genes, such as , , , , , , and in the liver. In summary, the hepatotoxicity of TiO NPs in young rats is closely related to oxidative stress, and the antioxidant effect of LGG might protect the harmful effects caused by TiO NPs.
二氧化钛纳米颗粒（TiO NPs）对哺乳动物的潜在毒性已引起广泛关注。接触TiO NPs的年轻人比成年人面临更高风险。在本研究中，探讨了鼠李糖乳杆菌（LGG）对TiO NPs诱导的幼鼠肝脏毒性的保护作用。结果表明，口服TiO NPs后接受LGG处理的四周龄大鼠可防止体重减轻，降低血液学指标（白细胞和中性粒细胞）以及血清生化指标（天冬氨酸转氨酶、丙氨酸转氨酶、天冬氨酸转氨酶/丙氨酸转氨酶和碱性磷酸酶）。此外，它减轻了肝脏的病理损伤（表现为肝细胞紊乱、嗜酸性增强、气球样变性并伴有血细胞），但并未降低肝脏中的钛含量。此外，逆转录定量聚合酶链反应（RT-qPCR）结果表明，LGG恢复了肝脏中抗氧化应激相关基因的表达，如 、 、 、 、 及 。总之，TiO NPs对幼鼠的肝毒性与氧化应激密切相关，LGG的抗氧化作用可能保护幼鼠免受TiO NPs引起的有害影响。
