Zhang Nan, Yang Zhiyou, Jin Yue, Cheng Shanshan, Yang Jiani, Wang Yu
Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Cancer Manag Res. 2021 Mar 29;13:2877-2883. doi: 10.2147/CMAR.S300738. eCollection 2021.
Recent studies have shown that circRNAs participate in ovarian cancer progression and act as potential biomarkers for ovarian cancer diagnosis and prognosis. In the present study, we aimed to investigate the expression pattern and prognostic significance of circ_0078607 in high-grade serous ovarian cancer (HGSOC).
The expression of circ_0078607 was detected by quantitative real-time polymerase chain reaction (qRT-PCR) in 49 cases of HGSOC. Clinical data of patients with HGSOC were retrospectively collected, and those patients were divided according to their expression of circ_0078607. Correlation between circ_0078607 and clinical features as well as the prognosis in patients with HGSOC was analyzed. -test and chi-square test were used to compare continuous and categorical variables. The Cox hazard regression model was used to assess prognostic factors. Both progression-free survival (PFS) and overall survival (OS) curves were generated by Kaplan-Meier method.
The expression of circ_0078607 was significantly downregulated in ovarian cancer tissues compared with adjacent non-cancerous tissues. Besides, patients with low circ_0078607 expression exhibited parameters associated with poor prognosis, including advanced FIGO stage and higher serum CA125 level. Kaplan-Meier survival curve analysis showed that patients with low circ_0078607 expression had shorter PFS and OS. Cox regression analysis showed that low expression of circ_0078607 was a predictor for poor PFS and OS in HGSOC patients.
Low expression of circ_0078607 might be an adverse prognostic indicator for HGSOC.
近期研究表明，环状RNA（circRNAs）参与卵巢癌进展，并作为卵巢癌诊断和预后的潜在生物标志物。在本研究中，我们旨在探讨环状RNA_0078607在高级别浆液性卵巢癌（HGSOC）中的表达模式及其预后意义。
采用定量实时聚合酶链反应（qRT-PCR）检测49例HGSOC患者中环状RNA_0078607的表达。回顾性收集HGSOC患者的临床资料，并根据环状RNA_0078607的表达情况对患者进行分组。分析环状RNA_0078607与HGSOC患者临床特征及预后的相关性。采用t检验和卡方检验比较连续变量和分类变量。采用Cox风险回归模型评估预后因素。无进展生存期（PFS）和总生存期（OS）曲线均采用Kaplan-Meier法绘制。
与癌旁非癌组织相比，卵巢癌组织中环状RNA_0078607的表达显著下调。此外，环状RNA_0078607低表达的患者表现出与预后不良相关的参数，包括国际妇产科联盟（FIGO）分期较晚和血清CA125水平较高。Kaplan-Meier生存曲线分析显示，环状RNA_0078607低表达的患者PFS和OS较短。Cox回归分析显示，环状RNA_0078607低表达是HGSOC患者PFS和OS不良的预测指标。
环状RNA_0078607低表达可能是HGSOC的不良预后指标。
