Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA.
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611-6131, USA.
Nanotheranostics. 2021 Mar 24;5(3):348-361. doi: 10.7150/ntno.58548. eCollection 2021.
Superparamagnetic iron oxide nanoparticle (SPION) tracers possessing long blood circulation time and tailored for magnetic particle imaging (MPI) performance are crucial for the development of this emerging molecular imaging modality. Here, single-core SPION MPI tracers coated with covalently bonded polyethyelene glycol (PEG) brushes were obtained using a semi-batch thermal decomposition synthesis with controlled addition of molecular oxygen, followed by an optimized PEG-silane ligand exchange procedure. The physical and magnetic properties, MPI performance, and blood circulation time of these newly synthesized tracers were compared to those of two commercially available SPIONs that were not tailored for MPI but are used for MPI: ferucarbotran and PEG-coated Synomag-D. The new tailored tracer has MPI sensitivity that is ~3-times better than the commercial tracer ferucarbotran and much longer circulation half-life than both commercial tracers (t=6.99 h for the new tracer, vs t=0.59 h for ferucarbotran, and t=0.62 h for PEG-coated Synomag-D).
超顺磁性氧化铁纳米颗粒（SPION）示踪剂具有较长的血液循环时间，并针对磁共振粒子成像（MPI）性能进行了优化，对于这种新兴的分子成像方式的发展至关重要。在这里，使用半分批热分解合成方法，通过控制添加分子氧，并进行优化的 PEG-硅烷配体交换步骤，获得了涂有共价键合的聚乙二醇（PEG）刷的单核 SPION MPI 示踪剂。这些新合成的示踪剂的物理和磁性能、MPI 性能以及血液循环时间与两种未针对 MPI 进行优化但用于 MPI 的市售 SPION 进行了比较：ferucarbotran 和 PEG 涂层的 Synomag-D。新的定制示踪剂的 MPI 灵敏度比商用示踪剂 ferucarbotran 好约 3 倍，血液循环半衰期比两种商用示踪剂长得多（新示踪剂的 t=6.99 h，ferucarbotran 的 t=0.59 h，PEG 涂层的 Synomag-D 的 t=0.62 h）。
