Time-Aligned Plane Wave Compounding Methods for High-Frame-Rate Shear Wave Elastography: Experimental Validation and Performance Assessment on Tissue Phantoms.

Shear wave elastography (SWE) is an ultrasonic technique able to quantitatively assess the mechanical properties of tissues by combining acoustic radiation force and ultrafast imaging. While utilizing coherent plane wave compounding enhances echo and shear wave motion signal-to-noise ratio (SNR), it also reduces the effective pulse repetition frequency (PRF), affecting the accuracy of the measurements of motion and, consequently, of material properties. It is important to maintain both high-motion SNR and PRF, particularly for the characterization of (material and/or geometrical) dispersive tissues such as arteries. This work proposes a method for SWE measurements with high SNR, while maintaining a high PRF, using conventional clinical ultrasound scanners. A time alignment process is applied after acquiring data from plane wave transmissions at different angles. The time alignment uses interpolation to obtain data points at higher frame rates, and the time-aligned data are compounded to increase the SNR. The method is used for SWE in tissue-mimicking phantoms of different stiffness and is compared with traditional plane wave compounding. Increases of 58% and 36% in spatial and temporal bandwidth compared with conventional plane wave compounding, respectively, can be achieved for SWE measurements of representative arterial stiffness values. Improvements in phase velocity accuracy and bandwidth in an arterial phantom are also described, to emphasize the beneficial advantage in dispersive cases.