细菌鞭毛马达旋转和切换的结构基础。
Structural basis of bacterial flagellar motor rotation and switching.
机构信息
Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT 06536, USA; Microbial Sciences Institute, Yale University, West Haven, CT 06516, USA.
Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT 06536, USA; Microbial Sciences Institute, Yale University, West Haven, CT 06516, USA.
出版信息
Trends Microbiol. 2021 Nov;29(11):1024-1033. doi: 10.1016/j.tim.2021.03.009. Epub 2021 Apr 14.
Abstract
The bacterial flagellar motor, a remarkable rotary machine, can rapidly switch between counterclockwise (CCW) and clockwise (CW) rotational directions to control the migration behavior of the bacterial cell. The flagellar motor consists of a bidirectional spinning rotor surrounded by torque-generating stator units. Recent high-resolution in vitro and in situ structural studies have revealed stunning details of the individual components of the flagellar motor and their interactions in both the CCW and CW senses. In this review, we discuss these structures and their implications for understanding the molecular mechanisms underlying flagellar rotation and switching.
摘要
细菌鞭毛马达是一种非凡的旋转机器，能够快速切换逆时针 (CCW) 和顺时针 (CW) 旋转方向，从而控制细菌细胞的迁移行为。该马达由一个双向旋转的转子和周围的产生扭矩的定子单元组成。最近的高分辨率体外和原位结构研究揭示了鞭毛马达各个组件的惊人细节，以及它们在 CCW 和 CW 两种状态下的相互作用。在这篇综述中，我们讨论了这些结构及其对理解鞭毛旋转和切换的分子机制的影响。
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