Shyam Prasad Shetty Bellipady, Chaya Sindaghatta Krishnarao, Kumar V Sravan, Mahendra Maheswarappa, Jayaraj Biligere Siddaiah, Lokesh Komarla Sundararaja, Ganguly Koustav, Mahesh Padukudru Anand
Department of Cardiothoracic and Vascular Surgery, JSS Medical College and Hospital, JSS Academy of Higher Education & Research, Mysuru 570015, India.
Department of Respiratory Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education & Research, Mysuru 570015, India.
Toxics. 2021 Apr 1;9(4):72. doi: 10.3390/toxics9040072.
Chronic obstructive pulmonary disease (COPD), the leading cause of mortality and morbidity worldwide, is characterized by abnormal activation of inflammatory cells. The increased pro-inflammatory cytokines, such as tumour necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), further amplify the inflammation. We evaluated the dose response relationship of IL-1β and TNF-α levels and severity of airflow limitation, and differential responses in IL-1β and TNF-α between biomass COPD (BMS-COPD) and tobacco smoke COPD (TS-COPD) using a case control design in 160 subjects. Patients with COPD had higher serum levels of both IL-1β and TNF-α compared to healthy controls. A large difference in TNF-α was observed between TS-COPD and BMS-COPD, where TS-COPD patients had much higher levels. Serum IL-1β levels were higher in BMS-COPD. Levels of IL-1β correlated better with severity of airflow limitation than TNF-α levels. Both TNF-α and IL-1β levels had a negative linear relationship with Forced Expiratory Volume in 1st second (FEV1) and six-minute walk distance. The correlations were stronger with FEV1 than six-minute walk distance. The correlations of TNF-α and IL-1β with St George Respiratory Questionnaire (SGRQ) scores and body mass index (BMI) were not significant. In conclusion, the levels of pro-inflammatory cytokines TNF-α and IL-1β are differently elevated in TS-COPD and BMS-COPD, respectively.
慢性阻塞性肺疾病（COPD）是全球范围内导致死亡和发病的主要原因，其特征是炎症细胞异常激活。肿瘤坏死因子α（TNF-α）和白细胞介素1β（IL-1β）等促炎细胞因子增加，进一步加剧了炎症反应。我们采用病例对照设计，对160名受试者进行了评估，以研究IL-1β和TNF-α水平与气流受限严重程度之间的剂量反应关系，以及生物质所致COPD（BMS-COPD）和烟草烟雾所致COPD（TS-COPD）中IL-1β和TNF-α的差异反应。与健康对照组相比，COPD患者的血清IL-1β和TNF-α水平均较高。TS-COPD和BMS-COPD之间观察到TNF-α存在较大差异，其中TS-COPD患者的水平要高得多。BMS-COPD患者的血清IL-1β水平更高。与TNF-α水平相比，IL-1β水平与气流受限严重程度的相关性更好。TNF-α和IL-1β水平与第1秒用力呼气量（FEV1）和6分钟步行距离均呈负线性关系。与6分钟步行距离相比，与FEV1的相关性更强。TNF-α和IL-1β与圣乔治呼吸问卷（SGRQ）评分和体重指数（BMI）的相关性不显著。总之，促炎细胞因子TNF-α和IL-1β的水平在TS-COPD和BMS-COPD中分别有不同程度的升高。
