Tang Ning, Zheng Youbin, Jiang Xue, Zhou Cheng, Jin Han, Jin Ke, Wu Weiwei, Haick Hossam
School of Aerospace Science and Technology, Xidian University, Xi'an 710126, China.
Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Micromachines (Basel). 2021 Apr 14;12(4):430. doi: 10.3390/mi12040430.
Wound healing is a complex tissue regeneration process involving many changes in multiple physiological parameters. The pH and temperature of a wound site have long been recognized as important biomarkers for assessing wound healing status. For effective wound management, wound dressings integrated with wearable sensors and systems used for continuous monitoring of pH and temperature have received much attention in recent years. Herein, recent advances in the development of wearable pH and temperature sensors and systems based on different sensing mechanisms for wound status monitoring and treatment are comprehensively summarized. Challenges in the areas of sensing performance, infection identification threshold, large-area 3-dimensional detection, and long-term reliable monitoring in current wearable sensors/systems and emerging solutions are emphasized, providing critical insights into the development of wearable sensors and systems for wound healing monitoring and management.
伤口愈合是一个复杂的组织再生过程，涉及多个生理参数的诸多变化。长期以来，伤口部位的pH值和温度一直被视为评估伤口愈合状态的重要生物标志物。为了实现有效的伤口管理，近年来，集成了用于连续监测pH值和温度的可穿戴传感器及系统的伤口敷料受到了广泛关注。本文全面总结了基于不同传感机制的用于伤口状态监测和治疗的可穿戴pH值和温度传感器及系统的最新进展。强调了当前可穿戴传感器/系统在传感性能、感染识别阈值、大面积三维检测以及长期可靠监测等方面的挑战和新兴解决方案，为用于伤口愈合监测和管理的可穿戴传感器及系统的发展提供了关键见解。
