Méndez Lucía, Medina Isabel
Instituto de Investigaciones Marinas-Consejo Superior de Investigaciones Científicas (IIM-CSIC), Eduardo Cabello 6, E-36208 Vigo, Spain.
Molecules. 2021 Apr 22;26(9):2438. doi: 10.3390/molecules26092438.
Polyphenols and omega-3 polyunsaturated fatty acids from fish oils, i.e., eicosapentaenoic and docosahexaenoic acids, are well-recognized nutraceuticals, and their single antioxidant and anti-inflammatory properties have been demonstrated in several studies found in the literature. It has been reported that the combination of these nutraceuticals can lead to three-fold increases in glutathione peroxidase activity, two-fold increases in plasma antioxidant capacity, decreases of 50-100% in lipid peroxidation, protein carbonylation, and urinary 8-isoprotanes, as well as 50-200% attenuation of common inflammation biomarkers, among other effects, as compared to their individual capacities. Therefore, the adequate combination of those bioactive food compounds and their single properties should offer a powerful tool for the design of successfully nutritional interventions for the prevention and palliation of a plethora of human metabolic diseases, frequently diet-induced, whose etiology and progression are characterized by redox homeostasis disturbances and a low-grade of chronic inflammation. However, the certain mechanisms behind their biological activities, in vivo interaction (both between them and other food compounds), and their optimal doses and consumption are not well-known yet. Therefore, we review here the recent evidence accumulated during the last decade about the cooperative action between polyphenols and fish oils against diet-related metabolic alterations, focusing on the mechanisms and pathways described and the effects reported. The final objective is to provide useful information for strategies for personalized nutrition based on these nutraceuticals.
来自鱼油的多酚和ω-3多不饱和脂肪酸，即二十碳五烯酸和二十二碳六烯酸，是广为人知的营养保健品，它们单一的抗氧化和抗炎特性已在文献中的多项研究中得到证实。据报道，这些营养保健品联合使用可使谷胱甘肽过氧化物酶活性提高三倍，血浆抗氧化能力提高两倍，脂质过氧化、蛋白质羰基化和尿8-异前列腺素降低50-100%，常见炎症生物标志物的水平降低50-200%，以及产生其他效果，与它们各自单独使用时相比。因此，这些生物活性食品化合物的适当组合及其单一特性应为设计成功的营养干预措施提供有力工具，以预防和缓解大量人类代谢疾病，这些疾病通常由饮食引起，其病因和进展的特征是氧化还原稳态紊乱和低度慢性炎症。然而，它们生物活性背后的特定机制、体内相互作用（它们之间以及与其他食品化合物之间）以及它们的最佳剂量和摄入量尚不清楚。因此，我们在此回顾过去十年中积累的关于多酚和鱼油协同作用对抗与饮食相关的代谢改变的最新证据，重点关注所描述的机制和途径以及所报道的效果。最终目标是为基于这些营养保健品的个性化营养策略提供有用信息。
